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Effects of the GPR40 agonist TAK-875 on [Ca2+]i and EETs on [3H]TAK-875–specific binding in HEK293 + GPR40 cells. A, effect of the GPR40 agonist TAK-875 on [Ca2+]i in the presence and absence of the GPR40 antagonist GW1100 (10 μm). B, effect of 11,12- and 14,15-EET on the specific binding of [3H]TAK-875 to HEK293 + GPR40 membranes. Each value represents the mean ± S.E. for n = 6–9. veh, vehicle.
