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. 2018 Jun 6;201(2):714–724. doi: 10.4049/jimmunol.1700884

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Copyright © 2018 The Authors

This article is distributed under the terms of the CC BY 4.0 Unported license.

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FIGURE 1. — Zaprinast, but not CXCL17, is able to promote interactions between β-arrestin-2 and isoforms and species orthologs of GPR35. Following coexpression of C-terminally eYFP-tagged forms of human GPR35a (A), human GPR35B (B), mouse (C), or rat (D) GPR35 and Renilla luciferase-tagged β-arrestin-2, the indicated concentrations of the GPR35 agonist zaprinast (filled symbols) or CXCL17 (open symbols) were added, and induced interactions between GPCR35 and β-arrestin-2 were assessed 5 min later by measuring bioluminescence resonance energy transfer.