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. 2018 Jun 26;9:1358. doi: 10.3389/fmicb.2018.01358

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Copyright © 2018 Guo, Zhang, Lu, Liu, Chen, Li, Deng and Wen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ligands on SAV4189 DNA-binding activity. (A) EMSAs of His₆-SAV4189 with various antibiotics. 125 nM His₆-SAV4189 was used for Apr and Kan; 62.5 nM His₆-SAV4189 was used for other antibiotics. DMSO was used as solvent control. (B) Effects of HygB (10 μg/ml) and Thi (diluted in DMSO; final concentration 5 μg/ml) on transcription of SAV4189 target genes in vivo. Control: no antibiotic or DMSO added. DMSO: DMSO (but no antibiotic) added. Value of each gene was shown as fold change relative to control value, defined as 1. NS, not significant; ^∗∗∗P< 0.001.