Table 3.
Enrichment-analysis for downregulated mRNAs in α-Gal(−/0) vs. wildtype mice using Gene Ontology and KEGG pathway annotations.
| Pathway ID | Pathway description | Count in network | False discovery rate | ||
|---|---|---|---|---|---|
| BIOLOGICAL PROCESSES (GO) | |||||
| GO.0050789 | Regulation of biological process | 94 | 0.0382 | ||
| GO.0050794 | Regulation of cellular process | 91 | 0.0355 | ||
| GO.0048518 | Positive regulation of biological process | 61 | 0.0466 | ||
| GO.0048583 | Regulation of response to stimulus | 43 | 0.0350 | ||
| GO.0051239 | Regulation of multicellular organismal process | 40 | 0.0073 | ||
| GO.0010646 | Regulation of cell communication | 39 | 0.0355 | ||
| GO.0023051 | Regulation of signaling | 37 | 0.0455 | ||
| GO.0002376 | Immune system process | 35 | < 0.0001 | ||
| GO.0006955 | Immune response | 26 | < 0.0001 | ||
| GO.0006952 | Defense response | 22 | 0.0073 | ||
| GO.0040011 | Locomotion | 21 | 0.0355 | ||
| GO.0051241 | Negative regulation of multicellular organismal process | 20 | 0.0466 | ||
| GO.0051050 | Positive regulation of transport | 19 | 0.0355 | ||
| GO.0001817 | Regulation of cytokine production | 17 | 0.0014 | ||
| GO.0030155 | Regulation of cell adhesion | 15 | 0.0355 | ||
| GO.0045087 | Innate immune response | 14 | 0.0073 | ||
| GO.0006935 | Chemotaxis | 13 | 0.0244 | ||
| GO.0002252 | Immune effector process | 12 | 0.0244 | ||
| GO.0007159 | Leukocyte cell-cell adhesion | 10 | 0.0423 | ||
| GO.0001818 | Negative regulation of cytokine production | 9 | 0.0244 | ||
| GO.2000249 | Regulation of actin cytoskeleton reorganization | 4 | 0.0438 | ||
| GO.0032606 | Type I interferon production | 3 | 0.0355 | ||
| GO.0002880 | Regulation of chronic inflammatory response to non-antigenic stimulus | 2 | 0.0466 | ||
Whole genome was used as statistical background.