Figure 3.

Validation of cerebellum as reference region for [¹¹C]ABP688 in mice. (A) Average parametric V_T images during baseline scan (BL) and following administration of MPEP (6 mg/kg) 10 min before tracer injection in WT mice. (B) SUV time-activity curves for different brain region during baseline and blocking scans. (C) V_T (Logan) quantification showed a statistically significant reduction in mGluR5-rich regions, while no significant changes were found in cerebellum. n = 4 per condition. ****p < 0.0001. BL, baseline; MPEP, 1,2-methyl-6-(phenylethynyl)-pyridine; STR, striatum; CTX, cortex; HIP, hippocampus; CB, cerebellum.