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. 2018 Jun 29;9:516. doi: 10.3389/fneur.2018.00516

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Copyright © 2018 Verhaeghe, Bertoglio, Kosten, Thomae, Verhoye, Van Der Linden, Wyffels, Stroobants, Wityak, Dominguez, Mrzljak and Staelens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of spatial normalization approaches for [¹¹C]ABP688 V_T regional quantification. (A) Correlation between V_T values in striatum (left) and cortex (right) based on individual MR images- and PET template-based spatial normalizations. Pearson's correlation test. Dashed line represents identity line. (B) Bland-Altman plot to compare the spatial normalization approaches in striatum (left) and cortex (right). The bias between the two approaches corresponds to the difference between the mean (red dashed line) and X axis (solid line). The dotted lines represent the 95% limits of agreement (mean difference ± 1.96 × SD of the differences), respectively. WT, wild type; HET, heterozygous.