Figure 6.

Reproducibility of test-retest quantification for [¹¹C]ABP688. Correlations of the volume of distribution (V_T) (A) and binding potential (BP_ND) (B) for the regions of interest in both WT and HET Q175 mice (n = 5 per genotype). Pearson's correlation test. Bland-Altman plot to compare test-retest quantification of V_T (C) and BP_ND (D). The bias between the two approaches corresponds to the difference between the mean (red dashed line) and X axis (solid line). The dotted lines represent the 95% limits of agreement (mean difference ± 1.96 x SD of the differences), respectively. (E) Average parametric images (n = 5) representing the V_T (left) and BP_ND (right) for both WT and HET Q175 mice. STR, striatum; HIP, hippocampus; THAL, thalamus; CTX, cortex; WT, wild type; HET, heterozygous.