Table 2.
Reproducibility of test-retest parameters for [11C]ABP688 volume of distribution (VT) and binding potential (BPND).
| Region | WT Q175 | HET Q175 | ||||||
|---|---|---|---|---|---|---|---|---|
| Test | Retest | Rel. Diff. (%) | Test | Retest | Rel. Diff. (%) | ICC | COV (%) | |
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | ||||
| VT (LOGAN) | ||||||||
| Striatum | 1.95 ± 0.60 | 2.03 ± 0.32 | 3.83 ± 14.9% | 1.83 ± 0.14 | 1.79 ± 0.30 | 1.92 ± 8.2% | 0.57 | 9.4 ± 7.2% |
| Cortex | 1.59 ± 0.49 | 1.63 ± 0.26 | 2.36 ± 15.1% | 1.56 ± 0.13 | 1.52 ± 0.25 | 2.37 ± 8.3% | 0.61 | 8.7 ± 6.8% |
| Hippocampus | 1.76 ± 0.52 | 1.83 ± 0.28 | 3.91 ± 17.9% | 1.74 ± 0.13 | 1.70 ± 0.28 | 1.99 ± 8.2% | 0.46 | 9.3 ± 7.0% |
| Thalamus | 1.49 ± 0.44 | 1.53 ± 0.24 | 2.28 ± 14.9% | 1.46 ± 0.11 | 1.40 ± 0.20 | 4.07 ± 7.4% | 0.35 | 9.1 ± 7.4% |
| BPND (SRTM) | ||||||||
| Striatum | 1.16 ± 0.14 | 1.15 ± 0.09 | 1.17 ± 6.3% | 0.97 ± 0.13 | 0.98 ± 0.14 | 1.09 ± 8.6% | 0.54 | 9.9 ± 6.9% |
| Cortex | 0.76 ± 0.08 | 0.74 ± 0.05 | 1.80 ± 5.7% | 0.68 ± 0.10 | 0.69 ± 0.11 | 2.24 ± 9.6% | 0.62 | 9.3 ± 6.1% |
| Hippocampus | 0.96 ± 0.11 | 0.94 ± 0.14 | 2.48 ± 6.7% | 0.85 ± 0.10 | 0.88 ± 0.14 | 3.49 ± 9.0% | 0.53 | 9.7 ± 6.6% |
| Thalamus | 0.65 ± 0.08 | 0.64 ± 0.06 | 2.67 ± 7.1% | 0.57 ± 0.08 | 0.57 ± 0.08 | 0.59 ± 9.2% | 0.32 | 10.2 ± 7.7% |
SD, standard deviation; WT, wild type; HET, heterozygous; Rel. Diff., relative difference; COV, coefficient of variation; ICC, intraclass correlation coefficient; VT, volume of distribution; BPND, binding potential; SRTM, simplified reference tissue model.