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. 2018 Jun 27;9:1470. doi: 10.3389/fimmu.2018.01470

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Copyright © 2018 Cowton, Singer, Gifford and Patel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regions of E2 targeted by broadly neutralizing antibodies. (A) Epitope 1 (412–423) is flexible. The structure of this region has been solved bound to several broadly neutralizing antibodies. In AP33 (blue) (PDB 4GAG) and HCV1 (green) (PDB 4DGV), this region forms a β-hairpin structure. In HC33.1 (red) (PDB 4XVJ), it has an intermediate structure between a β-hairpin and a coil and in 3/11 (purple) (PDB 4WHT), it has an extended conformation. (B) The core E2 structure (PDB 4MWF) with Epitope 2 (434–446) in magenta, Epitope 3 (525–535) in cyan, and Epitope 4 (611–617) in blue.