Table 1.
Broadly neutralizing antibodies and their epitopes analyzed in the study.
| Name | E2-binding residues | Region targeted | Identification of residues | Reference |
|---|---|---|---|---|
| AR4A | Y201, T204, N205, D206, R657, L692, D698 | E1E2 | Mutagenesis | (32) |
| AR5A | Y201, T204, N205, D206, R639, R657 | E1E2 | Mutagenesis | (32) |
| J6.36 | F403, G406 | Hypervariable region 1 (HVR1) | Mutagenesis | (33) |
| J6.103 | F403, G406 | HVR1 | Mutagenesis | (33) |
| H77.16 | G406, N410, I411 | HVR1 | Mutagenesis | (33) |
| HC33.4 | K408, L413, W420 | HVR1, Epitope 1 | Mutagenesis | (34) |
| HC33.8 | K408, L413, G418, W420 | HVR1, Epitope 1 | Mutagenesis | (34) |
| HC33.29 | K408, L413, G418, W420 | HVR1, Epitope 1 | Mutagenesis | (34) |
| AP33 | L413, N415, G418, W420 | Epitope 1 | Structure | (17, 35, 36) |
| Hu5B3.v3 | L413, N417, W420, I422 | Epitope 1 | Structure | (37) |
| HC33.1 | L413, G418, W420 | Epitope 1 | Structure | (34, 38) |
| HC33.32 | L413, G418, W420 | Epitope 1 | Mutagenesis | (34) |
| HCV1 | L413, N415, G418, W420 | Epitope 1 | Structure | (39, 40) |
| 95-2 | L413, W420 | Epitope 1 | Mutagenesis | (39) |
| H77.39 | N415, N417 | Epitope 1 | Mutagenesis | (33) |
| 3/11 | N415, W420, H421 | Epitope 1 | Structure | (41–43) |
| Mab24 | T416, G418, W420, H421 | Epitope 1 | Mutagenesis | (44) |
| HC84.22 | W420, N428, C429, W437, L441, F442, Y443, W616 | Epitope 1, 2, and 4 | Mutagenesis | (27, 45) |
| HC84.23 | W420, N428, C429, W437, L441, F442, Y443, W616 | Epitope 1, 2, and 4 | Mutagenesis | (27, 45) |
| AR3C | T425, N428, C429, L438, L441, F442, Y443, W529 | Epitope 2 and 3 | Structure | (24–26) |
| e20 | T425, L427, N428, W437, F442, W529, G530, D535, W616 | Epitope 2 and 3 | Mutagenesis | (46–48) |
| HC-11 | T425, N428, C429, G436, W437, L438, F442, Y443, D520, G530, D535 | Epitope 2 and 3 | Mutagenesis | (27, 49) |
| HC-1 | C429, W529, G530, D535 | Epitope 3 | Mutagenesis | (49, 50) |
| HC84.20 | C429, L441, Y613, W616 | Epitope 2 and 4 | Mutagenesis | (27, 34) |
| HC84.21 | C429, L441, F442, Y443 | Epitope 2 | Mutagenesis | (27, 34) |
| HC84.24 | C429, F442, Y443 | Epitope 2 | Mutagenesis | (27, 34) |
| HC84.25 | C429, L441, F442, W616 | Epitope 2 and 4 | Mutagenesis | (27, 34) |
| HC84.27 | C429, L441, F442, Y443, K446, W616 | Epitope 2 and 4 | Structure | (27, 34, 51) |
| mAb#8 | W437, L438 | Epitope 2 | Structure | (52, 53) |
| mAb#41 | W437, L438 | Epitope 2 | Peptide mapping | (52) |
| CBH-2 | W437, A439, G530, D535 | Epitope 2 and 3 | Mutagenesis | (49) |
| HC84.1 | L441, F442 | Epitope 2 | Structure | (34, 51) |
| HC84.26 | L441, F442 | Epitope 2 | Mutagenesis | (34) |
| 1:7 | G523, T526, Y527, W529, G530, D535 | Epitope 3 | Mutagenesis | (54) |
| A8 | G523, T526, Y527, W529, G530, D535 | Epitope 3 | Mutagenesis | (54) |
| MAb44 | G523, P525, N540, W549, Y613 | Epitope 3 and 4 | Mutagenesis | (44) |
| J6.27 | A524, W529 | Epitope 3 | Mutagenesis | (33) |
| H77.31 | W529, G530, D533 | Epitope 3 | Mutagenesis | (33) |
aItalicized residues are not in Epitopes 1–4. Numbering is according to the H77 polyprotein. Antibodies are listed in numerical order according to the first residue of their epitope.