Table 2.
The lowest conservation (%) for each bNAb epitope binding motif across genotypes.
| Name | Gt1% Con | Gt2% Con | Gt3% Con | Gt4% Con | Gt5% Con | Gt6% Con | Gt7% Con | Sum% Con | No. gt >90% | Region targeted | Rank |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AR4A | 99.79 | 99.78 | 99.72 | 99.15 | 99.65 | 99.86 | 100 | 697.95 | 7 | E1E2 | 2 |
| AR5A | 99.79 | 99.78 | 99.8 | 99.15 | 99.65 | 99.65 | 100 | 697.82 | 7 | E1E2 | 3 |
| J6.36 | 85.02 | 85.28 | 81.48 | 92.85 | 92.76 | 91.93 | 0 | 529.32 | 3 | Hypervariable region 1 (HVR1) | 21= |
| J6.103 | 85.02 | 85.28 | 81.48 | 92.85 | 92.76 | 91.93 | 0 | 529.32 | 3 | HVR1 | 21= |
| H77.16 | 59.4 | 39.75 | 4.8 | 18.6 | 2.72 | 25.16 | 0 | 150.43 | 0 | HVR1 | 29 |
| HC33.4 | 36.58 | 33.51 | 21.96 | 16.88 | 29.53 | 49.3 | 0 | 187.76 | 0 | HVR1, Epitope 1 | 25= |
| HC33.8 | 36.58 | 33.51 | 21.96 | 16.88 | 29.53 | 49.3 | 0 | 187.76 | 0 | HVR1, Epitope 1 | 25= |
| HC33.29 | 36.58 | 33.51 | 21.96 | 16.88 | 29.53 | 49.3 | 0 | 187.76 | 0 | HVR1, Epitope 1 | 25= |
| AP33 | 97.57 | 72.57 | 86.88 | 94.94 | 85.82 | 95.62 | 100 | 633.4 | 4 | Epitope 1 | 11= |
| Hu5B3.v3 | 96.05 | 97.19 | 97.24 | 98.05 | 96.30 | 88.03 | 100 | 672.86 | 6 | Epitope 1 | 8 |
| HC33.1 | 99.66 | 99.56 | 99.85 | 99.87 | 97.06 | 99.83 | 100 | 695.83 | 7 | Epitope 1 | 5= |
| HC33.32 | 99.66 | 99.56 | 99.85 | 99.87 | 97.06 | 99.83 | 100 | 695.83 | 7 | Epitope 1 | 5= |
| HCV1 | 97.57 | 72.57 | 86.88 | 94.94 | 85.82 | 95.62 | 100 | 633.4 | 4 | Epitope 1 | 11= |
| 95-2 | 99.73 | 99.56 | 99.9 | 100 | 97.06 | 99.83 | 100 | 696.08 | 7 | Epitope 1 | 4 |
| H77.39 | 97.57 | 72.57 | 86.88 | 94.94 | 85.82 | 95.62 | 100 | 633.4 | 4 | Epitope 1 | 11= |
| 3/11 | 97.57 | 72.57 | 86.88 | 94.94 | 85.82 | 95.62 | 100 | 633.4 | 4 | Epitope 1 | 11= |
| Mab24 | 91.08 | 63.21 | 84.21 | 85.73 | 86.67 | 80.96 | 100 | 591.86 | 2 | Epitope 1 | 15 |
| HC84.22 | 59.59 | 4.2 | 0 | 0.92 | 0 | 0.51 | 0 | 65.22 | 0 | Epitope 1, 2, and 4 | 32= |
| HC84.23 | 59.59 | 4.2 | 0 | 0.92 | 0 | 0.51 | 0 | 65.22 | 0 | Epitope 1, 2, and 4 | 32= |
| AR3C | 42.23 | 28.13 | 15.14 | 46.2 | 7.69 | 13.59 | 0 | 152.98 | 0 | Epitope 2 and 3 | 28 |
| e20 | 59.59 | 4.2 | 0 | 0.92 | 0 | 0.51 | 0 | 65.22 | 0 | Epitope 2, 3, and 4 | 32= |
| HC-11 | 42.23 | 4.2 | 0 | 0.92 | 0 | 0.51 | 0 | 47.86 | 0 | Epitope 2 and 3 | 36= |
| HC-1 | 99.78 | 98.49 | 86.15 | 99.15 | 100 | 98.62 | 100 | 682.19 | 5 | Epitope 3 | 7 |
| HC84.20 | 99.81 | 99.58 | 99.8 | 99.51 | 100 | 100 | 100 | 698.7 | 4 | Epitope 2 and 4 | 1 |
| HC84.21 | 81.85 | 99.12 | 74.83 | 96.08 | 20.51 | 90.47 | 100 | 562.86 | 4 | Epitope 2 | 16= |
| HC84.24 | 81.85 | 99.12 | 74.83 | 96.08 | 20.51 | 90.47 | 100 | 562.86 | 4 | Epitope 2 | 16= |
| HC84.25 | 81.85 | 99.12 | 74.83 | 96.08 | 20.51 | 90.47 | 100 | 562.86 | 4 | Epitope 2 and 4 | 16= |
| HC84.27 | 69.80 | 16.37 | 74.83 | 85.60 | 20.51 | 66.97 | 0 | 334.08 | 0 | Epitope 2 and 4 | 24 |
| mAb#8 | 42.23 | 4.2 | 0 | 0.92 | 0 | 0.51 | 0 | 47.86 | 0 | Epitope 2 | 36= |
| mAb#41 | 42.23 | 4.2 | 0 | 0.92 | 0 | 0.51 | 0 | 47.86 | 0 | Epitope 2 | 36= |
| CBH-2 | 59.59 | 4.2 | 0 | 0.92 | 0 | 0.51 | 0 | 65.22 | 0 | Epitope 2 and 3 | 32= |
| HC84.1 | 81.85 | 99.12 | 74.83 | 96.08 | 20.51 | 90.47 | 100 | 562.86 | 4 | Epitope 2 | 16= |
| HC84.26 | 81.85 | 99.12 | 74.83 | 96.08 | 20.51 | 90.47 | 100 | 562.86 | 4 | Epitope 2 | 16= |
| 1:7 | 95.81 | 98.49 | 86.15 | 97.86 | 94.74 | 98.62 | 100 | 671.67 | 6 | Epitope 3 | 9= |
| A8 | 95.81 | 98.49 | 86.15 | 97.86 | 94.74 | 98.62 | 100 | 671.67 | 6 | Epitope 3 | 9= |
| Mab44 | 98.73 | 99.43 | 4.03 | 99.51 | 100 | 0.56 | 100 | 502.26 | 5 | Epitope 3 and 4 | 23 |
| J6.27 | 61.23 | 25.14 | 38.41 | 1.26 | 0 | 4.52 | 0 | 130.56 | 0 | Epitope 3 | 30 |
| H77.31 | 49.09 | 3.02 | 2.12 | 9.83 | 10.53 | 1.4 | 0 | 75.99 | 0 | Epitope 3 | 31 |
Shading denotes >90% conservation. Each antibody has been ranked from the most to the least conserved according to the sum of the lowest level of conservation (%) across all genotypes. An = symbol shows broadly neutralizing antibodies that have equivalent rank.