Table 4.
The most prevalent sequences for the complete bNAb epitope motifs.
| bNAb | Sequence | Percentage of sequences (%) |
Total no. sequences | Gt range | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gt1 | Gt2 | Gt3 | Gt4 | Gt5 | Gt6 | Gt7 | ||||
| HC84.20 | C/L/Y/W | 98.6 | 99.2 | 99.5 | 99.5 | 100 | 100 | 100 | 11,379 | 1–7 |
| C/L/H/W | 1.10 | 0 | 0 | 0 | 0 | 0 | 0 | 89 | 1 | |
| AR4A | Y/TND/R/L/D | 99.3 | 99.2 | 99.2 | 97.5 | 100 | 99.6 | 100 | 9,704 | 1–7 |
| Y/SND/R/L/D | 0.11 | 0 | 0 | 1.97 | 0 | 0 | 0 | 12 | 1, 4 | |
| AR5A | Y/TND/R/R | 99.5 | 99.5 | 99.4 | 97.5 | 100 | 99.1 | 100 | 9,741 | 1–7 |
| Y/SND/R/R | 0.11 | 0 | 0 | 1.97 | 0 | 0 | 0 | 12 | 1, 4 | |
| 95/2 | L/W | 99.6 | 99.6 | 99.9 | 100 | 96.3 | 99.7 | 100 | 29,658 | 1–7 |
| L/R | 0.15 | 0.07 | 0.05 | 0 | 0 | 0.17 | 0 | 39 | 1, 2, 3, 6 | |
| P/W | 0.07 | 0 | 0.05 | 0 | 0 | 0 | 0 | 19 | 1, 3 | |
| L/a | 0.05 | 0.07 | 0 | 0 | 0 | 0 | 0 | 12 | 1, 2 | |
| L/C | 0.04 | 0 | 0 | 0 | 0.75 | 0 | 0 | 11 | 1, 5 | |
| HC33.1 and HC33.32 | L/G/W | 99.3 | 99.3 | 99.7 | 99.9 | 94.8 | 99.5 | 100 | 29,565 | 1–7 |
| L/N/W | 0.19 | 0 | 0.03 | 0 | 0 | 0 | 0 | 45 | 1,3 | |
| L/G/R | 0.15 | 0.07 | 0.05 | 0 | 0 | 0.17 | 0 | 39 | 1, 2, 3, 6 | |
| L/D/W | 0.07 | 0 | 0.10 | 0 | 0 | 0 | 0 | 21 | 1, 3 | |
| P/G/W | 0.07 | 0 | 0.05 | 0 | 0 | 0 | 0 | 19 | 1, 3 | |
| L/S/W | 0.05 | 0.07 | 0 | 0 | 0.75 | 0.17 | 0 | 15 | 1, 2, 5, 6 | |
| L/G/a | 0.05 | 0.07 | 0 | 0 | 0 | 0 | 0 | 12 | 1, 2 | |
| L/G/C | 0.04 | 0 | 0 | 0 | 0.75 | 0 | 0 | 11 | 1, 5 | |
| HC-1 | C/WG/D | 99.4 | 98.1 | 85.7 | 98.3 | 100 | 98.6 | 100 | 13,764 | 1–7 |
| C/FG/D | 0.04 | 0 | 13.4 | 0.43 | 0 | 1.08 | 0 | 380 | 1, 3, 4, 6 | |
| C/WG/G | 0.12 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 1 | |
| C/RG/D | 0.07 | 0 | 0.11 | 0 | 0 | 0 | 0 | 10 | 1, 3 | |
| 1:7 and A8 | G/TY/WG/D | 91.9 | 97.5 | 82.9 | 96.6 | 94.7 | 97.2 | 100 | 12,806 | 1–7 |
| G/TF/WG/D | 3.64 | 0 | 2.6 | 2.14 | 0 | 1.10 | 0 | 453 | 1, 3, 4, 6 | |
| G/TY/FG/D | 0.02 | 0 | 13.4 | 0.43 | 0 | 1.10 | 0 | 377 | 1, 3, 4, 6 | |
| G/AY/WG/D | 3.33 | 0.19 | 0 | 0 | 0 | 0 | 0 | 341 | 1, 2 | |
| G/TH/WG/D | 0.37 | 0.19 | 0.07 | 0 | 0 | 0 | 0 | 41 | 1, 2, 3 | |
| G/TY/WG/G | 0.11 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 1 | |
| Hu5B3.v3 | L/N/W/I | 95.0 | 96.1 | 96.1 | 97.7 | 92.5 | 87.0 | 100 | 27,806 | 1–7 |
| L/N/W/L | 2.37 | 0.07 | 0.03 | 0.65 | 0 | 0.51 | 0 | 555 | 1, 2, 3, 4, 6 | |
| L/N/W/V | 1.40 | 2.59 | 2.70 | 1.30 | 0 | 11.3 | 0 | 537 | 1, 2, 3, 4, 6 | |
| L/S/W/I | 0.40 | 0.37 | 0.23 | 0 | 0.75 | 0.34 | 0 | 109 | 1, 2, 3, 5, 6 | |
| L/D/W/I | 0.16 | 0.15 | 0.05 | 0 | 0 | 0.17 | 0 | 42 | 1, 2, 3, 6 | |
| L/N/R/I | 0.13 | 0.07 | 0.05 | 0 | 0 | 0.17 | 0 | 35 | 1, 2, 3, 6 | |
| L/Q/W/I | 0 | 0 | 0.62 | 0 | 1.50 | 0 | 0 | 26 | 3, 5 | |
| L/N/W/T | 0.10 | 0.07 | 0.05 | 0 | 0 | 0 | 0 | 25 | 1, 2, 3 | |
| P/N/W/I | 0.07 | 0 | 0.05 | 0 | 0 | 0 | 0 | 15 | 1, 3 | |
| L/R/W/I | 0.05 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 1 | |
| L/N/a/I | 0.05 | 0.07 | 0 | 0 | 0 | 0 | 0 | 12 | 1, 2 | |
| L/N/C/I | 0.04 | 0 | 0 | 0 | 0.75 | 0 | 0 | 11 | 1, 5 | |
aSignifies a stop codon, sequence differences are shown in bold.