Fig 1.

Cisplatin induces weight loss and muscle atrophy in mice. Four sets of treatment group were used with CD2F1 mice. In group 1, mice were injected with saline (control); in group 2, mice were injected with saline and then treated with cisplatin at days 7, 10, and 14 post-injection (cisplatin); in group 3, mice were injected with C-26 tumor cells (C-26); in group 4, mice were injected with C-26 cells then treated with cisplatin at days 7, 10, and 14 post injection (C-26/cisplatin). (A) Following treatments, body weights (n=4, each group) were recorded at indicated days. (B) Gastrocnemius muscle weight (n=6 each group) were recorded in grams on day 17 post injection. (C) C-26 tumors were removed from untreated and cisplatin treated mice and weighed. (D) H&E stained cryosections of gastrocnemius muscles were analyzed (n=4 per group). (E) Fiber diameter was measured from H&E muscle sections from(D).