Table 3.

Prevalence of IgG antibodies in sera from HS, reacting to SV40 Tag mimotopes A and D reported in different studies, and OS patients analyzed in this investigation.

Human serum	Articles	Age years; Mean age range	Number of SV40 Tag A+D positive samples/samples analyzed (%)	P-Value
OS	This study	22; 6–76	87/249 (35)
HS	This study	21; 4–76	56/247 (23)	<0.01
HS1	Tognon et al., 2016	44;18–65	138/704 (20)	<0.0001
HS2	Mazzoni et al., 2017b	78; 66–100	60/273 (22)	<0.01
HS3	Mazzoni et al., 2017b	57; 22–91	49/254 (19)	<0.01
HS4	Mazzoni et al., 2017b	30; 18–40	36/180 (20)	<0.01

Human sera were from OS patients and HS. The prevalence of SV40 Tag antibodies among the cohorts of HS 1–4 were reported in previous articles, whereas the prevalence of SV40 Tag antibodies in OS sera were analyzed in this study, together with the new cohort of HS.

The prevalence of SV40 Tag antibodies in OS sera is statistically significant compared to HS and HS 1-4 (P < 0.01 and P < 0.0001).

Statistical analysis was performed using the Chi Square with Yates'correction.