Table III.
Immunohistochemical findings of iNOS, 8-OHdG, OGG1, MTH1, MUTYH and p53 in UC associated neoplasm compared with UC without neoplasm and normal colon.
| Variable | Group A UC associated neoplasm (n=23) | Group B UC without neoplasm (n=16) | Group C normal colon (n=17) | P-value Group A vs. Group B | P-value Group A vs. Group C | P-value Group B vs. Group C |
|---|---|---|---|---|---|---|
| iNOS | ||||||
| Score | 8 (4–8) | 7 (4–8) | 5 (0–8) | 0.1878 | 0.0002a | 0.0034a |
| 8-OHdG | ||||||
| Labeling index | 49.3 (10.4–78.1) | 53.6 (36.7–77) | 29.1 (5.4–58) | 0.4407 | 0.0034a | 0.0005a |
| OGG1 | ||||||
| Score | 4 (2–6) | 4 (1–6) | 1 (0–4) | 0.0227a | <0.0001a | 0.0011a |
| MTH1 | ||||||
| Score | 6 (2–6) | 4 (2–6) | 1 (0–4) | 0.0012a | <0.0001a | <0.0001a |
| MUTYH nuclear | ||||||
| Low (score 0) (%) | 19 (82.7) | 9 (56.3) | 4 (23.5) | 0.1461 | 0.0003a | 0.0799 |
| High (score 1) (%) | 4 (17.3) | 7 (43.7) | 13 (76.5) | |||
| Cytoplasmic | ||||||
| Low (score 1) (%) | 9 (39.1) | 7 (43.8) | 15 (88.2) | 1.0000 | 0.0019a | 0.0104a |
| High (score 2) (%) | 14 (60.9) | 9 (56.3) | 2 (11.8) | |||
| p53 protein | ||||||
| Positive (%) | 11 (47.8) | 0 (0) | Not done | 0.0009a | Not available | Not available |
| Negative (%) | 12 (52.1) | 16 (100) | Not done | |||
a
Statistically significant. In the parentheses, range is described for iNOS, 8-OHdG, OGG1 and MTH1, whereas percentage is described for other factors. Outside the parentheses, median scores are described for iNOS, 8-OHdG, OGG1 and MTH1, whereas case numbers are described for other factors.