Table IV.
Immunohistochemical findings of iNOS, 8-OHdG, OGG1, MTH1, MUTYH and p53 and TP53 mutation in UC associated carcinoma compared with UC associated dysplasia.
| Variable | Group A1UC associated carcinoma (n=14) | Group A2 UC associated dysplasia (n=9) | P-value |
|---|---|---|---|
| iNOS | |||
| Score | 8 (4–8) | 7 (4–8) | 0.7007 |
| 8-OHdG | |||
| Labeling index | 49.2 (10.4–78.1) | 49.3 (23.4–69.1) | 0.6821 |
| OGG1 | |||
| Score | 5 (2–6) | 4 (2–6) | 0.5623 |
| MTH1 | |||
| Score | 6 (2–6) | 4 (4–6) | 0.7209 |
| MUTYH nuclear | |||
| Low (score 0) (%) | 11 (78.6) | 8 (88.9) | 0.5241 |
| High (score 1) (%) | 3 (21.4) | 1 (11.1) | |
| Cytoplasmic | |||
| Low (score 1) (%) | 2 (14.3) | 7 (77.8) | 0.0023a |
| High (score 2) (%) | 12 (85.7) | 2 (22.2) | |
| p53 protein | |||
| Positive (%) | 4 (28.6) | 7 (77.8) | 0.0211a |
| Negative (%) | 10 (71.4) | 2 (22.2) | |
| TP53 mutationb | |||
| Positive (%) | 5 (35.7) | 5 (62.5) | 0.2248 |
| Negative (%) | 9 (64.3) | 3 (37.5) | |
a
Statistically significant.
b
One case with unsuccesful PCR for TP53 was excluded (n=22). In the parentheses, range is described for iNOS, 8-OHdG, OGG1 and MTH1, whereas percentage is described for other factors. Outside the parentheses, median scores are described for iNOS, 8-OHdG, OGG1 and MTH1, whereas case numbers are described for other factors.