Table VII.
The correlations between TP53 mutational status and clinicopathological factors or immunohistochemical features of UC-associated neoplasia (n=22)a.
| TP53 mutation | |||
|---|---|---|---|
| Variable | Positive (%) (n=10) | Negative (%) (n=12) | P-value |
| Age (year) | 46 (25–71) | 45.5 (26–77) | 0.8948 |
| Gender | |||
| Male (%) | 5 (50) | 8 (66.6) | 0.4285 |
| Female (%) | 5 (50) | 4 (33.3) | |
| Disease duration (year) | 14 (10–24) | 18.5 (0.5–35) | 0.9698 |
| iNOS | |||
| Score | 8 (6–8) | 7 (4–8) | 0.1099 |
| 8-OHdG | |||
| Labelling index (%) | 45.9 (23.4–78.1) | 50.7 (10.4–69.1) | 0.9212 |
| OGG1 | |||
| Score | 4 (2–6) | 6 (2–6) | 0.1028 |
| MTH1 | |||
| Score | 6 (4–6) | 4 (2–6) | 0.3515 |
| MUTYH nuclear | |||
| Low (score 0) (%) | 8 (80) | 10 (83.3) | 0.8403 |
| High (score 1) (%) | 2 (20) | 2 (16.7) | |
| Cytoplasmic | |||
| Low (score 1) (%) | 3 (30) | 5 (41.7) | 0.5711 |
| High (score 2) (%) | 7 (70) | 7 (58.3) | |
| p53 protein | |||
| Positive (%) | 5 (50) | 5 (41.7) | 0.6959 |
| Negative (%) | 5 (50) | 7 (58.3) | |
a
One case with unsuccessful PCR for TP53 was excluded. In the parentheses, range is described for age, disease duration, iNOS, 8-OHdG, OGG1 and MTH1, whereas percentage is described for other factors. Outside the parentheses, average years are described for age and disease duration, whereas case numbers are described for other factors.