Table II.
Kyoto Encyclopedia of Genes and Genomes pathway analysis of DEGs associated with non-small cell lung cancer.
| A, Upregulated DEGs | ||||
|---|---|---|---|---|
| Pathway ID | Name | Count | P-value | Genes |
| hsa04110 | Cell cycle | 25 | 8.4×10−11 | CDK1, CDC6, E2F3, DBF4, TTK, ESPL1, CDC20, CHEK1, MCM2, PTTG1, SFN, MCM4, CCNB1, CCNE2, CCNE1, CDC45, CDKN2A, CCNB2, MAD2L1, PLK1, PCNA, BUB1B, ORC6, ORC1, CCNA2 |
| hsa03030 | DNA replication | 10 | 8.8×10−6 | PRIM1, DNA2, RFC4, POLE2, PCNA, MCM2, RNASEH2A, MCM4, FEN1, RPA3 |
| hsa04115 | p53 signaling pathway | 13 | 1.2×10−5 | CDK1, CHEK1, SFN, PMAIP1, GTSE1, CCNB1, CCNE2, CCNE1, CDKN2A, CCNB2, SERPINB5, RRM2, IGFBP3 |
| hsa04512 | Extracellular matrix-receptor interaction | 11 | 2.0×10−3 | IBSP, COMP, COL3A1, COL1A2, COL1A1, COL11A1, THBS2, COL5A2, COL5A1, SPP1, HMMR |
| hsa04974 | Protein digestion and absorption | 11 | 3.0×10−3 | KCNN4, COL17A1, COL7A1, PRSS2, COL3A1, COL1A2, COL1A1, COL11A1, COL5A2, COL5A1, COL10A1 |
| B, Downregulated DEGs | ||||
| Pathway ID | Name | Count | P-value | Genes |
| hsa04610 | Complement and coagulation cascades | 16 | 4.2×10−6 | C7, C5AR1, C6, F8, SERPING1, C4BPA, C1QA, C8B, C1QB, VWF, CD55, THBD, SERPIND1, CFD, CPB2, PROS1 |
| hsa05144 | Malaria | 12 | 5.9×10−5 | CSF3, GYPC, ICAM1, ITGAL, SELP, IL6, CD36, PECAM1, ACKR1, TLR4, HBB, SELE |
| hsa04514 | Cell adhesion molecules | 20 | 3.1×10−4 | ICAM1, ITGAL, SELP, CLDN18, OCLN, PTPRM, CADM1, ICAM2, CLDN5, NECTIN3, HLA-DMA, CDH5, SIGLEC1, CD34, ITGA8, PECAM1, ESAM, JAM2, SELE, NEGR1 |
| hsa04360 | Axon guidance | 18 | 6.3×10−4 | ABLIM1, PLXNA2, ABLIM3, EFNB2, NTN4, DPYSL2, CXCL12, SLIT2, SLIT3, SEMA5A, SEMA6A, RND1, SEMA6D, FYN, SEMA3G, CFL2, SEMA3E, ROBO2 |
| hsa04924 | Renin secretion | 12 | 7.1×10−4 | AGTR1, ACE, ADRB2, ADRB1, PLCB4, PTGER4, GUCY1A2, GUCY1A3, NPR1, AQP1, CACNA1D, ITPR1 |
p53, tumor protein 53; DEGs, differentially expressed genes.