Table II.
Univariate and multivariate analysis of prognostic factors for overall survival.
| Variable | Univariate HR (95% CI) | P-value | Multivariate HR (95% CI) | P-value |
|---|---|---|---|---|
| Sex | ||||
| Male | 1 | |||
| Female | 0.672 (0.370–1.222) | 0.190 | ||
| Age (years) | ||||
| <60 | 1 | |||
| ≥60 | 1.193 (0.681–2.091) | 0.536 | ||
| Location | ||||
| Colon | 1 | |||
| Rectum | 1.257 (0.701–2.253) | 0.441 | ||
| Tumor size (cm) | ||||
| <5 | 1 | |||
| ≥5 | 0.915 (0.522–1.604) | 0.756 | ||
| pT classification | ||||
| T1-T3 | 1 | 1 | ||
| T4 | 2.257 (1.264–4.030) | 0.549 | 0.549 (0.236–1.280) | 0.165 |
| pN classification | ||||
| N0 | 1 | 1 | ||
| N1-N2 | 2.035 (1.155–3.585) | 0.012a | 0.480 (0.098–2.357) | 0.366 |
| AJCC stage | 0.004b | 0.007b | ||
| I | 1 | 1 | ||
| II | 0.210 (0.086–0.513) | 0.001b | 0.895 (0.096–8.308) | 0.922 |
| III | 0.274 (0.116–0.649) | 0.003b | 0.923 (0.114–7.495) | 0.940 |
| IV | 0.378 (0.168–0.848) | 0.018a | 0.191 (0.093–0.604) | 0.001b |
| Grade | ||||
| High | 1 | 1 | ||
| Low | 2.150 (1.209–3.825) | 0.008b | 0.614 (0.325–1.163) | 0.134 |
| Wdr82 expression | ||||
| Negative | 1 | 1 | ||
| Positive | 0.499 (0.272–0.916) | 0.032a | 1.980 (1.064–3.847) | 0.032a |
| H3K4me3 expression | ||||
| Negative | 1 | 1 | ||
| Positive | 2.283 (1.280–4.072) | 0.005b | 2.988 (1.591–5.612) | 0.001b |
| CEA | ||||
| Negative | 1 | 1 | ||
| Positive | 0.488 (0.695–2.140) | 0.487 | 0.206 (0.025–1.678) | 0.140 |
a
P<0.05
b
P>0.001. Wdr82, WD repeat domain 82; H3K4me3, Histone H3 trimethylation at lysine 4; HR, hazard ratio; CI, confidence interval; AJCC, American Joint Committee on Cancer; pN, primary nodes; pT, primary tumor; CEA, carcinoembryonic antigen.