Figure 2.

miR-210 Affects the Migratory Capacity and Morphology of PB-PACs

(A) Bar graph shows the capacity of PB-PACs engineered with pre- or anti-miR-210 to migrate toward SDF-1 (CXCL-12) or in the absence of chemoattratant (vehicle). *p < 0.05, **p < 0.01, ***p < 0.001 versus vehicle; ^#p < 0.05, ^##p < 0.01 versus SCR. Data shown as mean ± SEM, n = 6 donors. (B) Alteration of cell shape in response to miR-210 modulation. Representative images of phalloidin staining: round-shaped cells are indicated by yellow arrows. Scale bars, 50 μm. Bar graph indicates the average number of round-shaped cells, *p < 0.05. Data shown as mean ± SEM, n = 5 donors.