Table 1.

Recurrence‐free survival after surgery in patients with chronic hepatitis C

Variable	Number	MST (days)	Survival rate (years)			P‐value
			3	5	7
Age (years)
<65	21	3102	67	51	51	.72
≥65	38	1644	64	41	36
Gender
Female	11	1639	80	50	50	.60
Male	48	1339	61	42	38
Alcohol abuse
Presence	13	1319	53	35	23	.26
Absence	46	1784	69	47	47
Diabetes mellitus
Presence	17	1319	59	49	33	.44
Absence	42	1644	67	43	43
Obesity
Presence	18	731	30	22	22	<.01
Absence	41	1996	75	54	49
Dyslipidemia
Presence	12	NA	81	65	65	.22
Absence	47	1339	61	40	36
Hypertension
Presence	26	1303	50	35	28	.038
Absence	33	3102	76	51	51
HBc antibody
Positive	33	1639	74	43	43	.61
Negative	26	1784	52	46	39
Interval from IFNa (years)
≤5	39	1324	59	38	38	.22
>5	20	1996	77	55	47
T‐Bil (mg/dL)
<1.0	48	1339	60	41	38	.49
≥1.0	11	3102	82	53	53
Albumin (g/dL)
<4.0	14	1324	63	45	45	.88
≥4.0	45	1644	65	44	40
Platelet count (×104/mL)
<15	29	1319	62	41	35	.30
≥15	30	1784	68	48	48
ALT (IU/L)
>30	21	1784	68	46	46	.42
≤30	38	1639	63	42	37
α‐Fetoprotein (ng/mL)
>20	17	1784	55	46	46	.83
≤20	42	1639	69	43	38
Tumor size (cm)
>2.0	29	1303	54	45	45	.93
≤2.0	30	1644	75	38	30
Differentiation degreeb
Well, mod	45	1644	67	45	40	.72
Poor	14	1263	56	40	40
No. tumors
Single	50	1784	67	48	44	.075
Multiple	9	945	50	17	17
MVI
Presence	18	3102	59	59	59	>.99
Absence	41	1639	67	38	33
Hepatic steatosis
Positive	32	1319	56	43	37	.32
Negative	27	1784	75	46	46
Lobular inflammation
Positive	47	NA	62	41	41	.37
Negative	12	1324	75	64	54
Ballooning
Positive	24	1324	59	39	31	.33
Negative	35	1644	69	47	47
Liver cirrhosis
Presence	15	1028	44	44	44	.37
Absence	44	1644	72	44	40
Type of hepatic resection
Non‐anatomical	37	1303	51	25	25	.022
Anatomical	22	NA	79	66	60

^aInterval from the end of interferon therapy to the detection of hepatocellular carcinoma.

^bTumor differentiation: well, well‐differentiated; mod, moderately differentiated; poor, poorly differentiated.

ALT, alanine aminotransferase; HBc, hepatitis B core; IFN, interferon; MST, median survival time; MVI, microvascular invasion; NA, not applicable; T‐Bil, total bilirubin.