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. 2018 Jun 4;16(2):2097–2104. doi: 10.3892/ol.2018.8891

Figure 2.

Figure 2.

Effects of FUT8 on cell motility and proliferation. (A) Western blot analysis of EMT markers, p-AKT and AKT, detected in FUT8-overexpressed MCF10A cells. (B) FUT8-overexpressed MCF10A cells were subjected to wound healing and Transwell assay. *P<0.05, ***P<0.001 vs. Mock. (C) Proliferation analysis of FUT8-overexpressed MCF10A cells. (D) Western blot analysis of p-AKT, AKT and FUT8 expression in MCF10A and MDA-MB-231 cells. (E) Western blot analysis of p-AKT, AKT and FUT8 in FUT8-knockdown MDA-MB-231 cells. (F) Wound healing and Transwell assay (Scale bar, 200 µm; ×100 magnification) in FUT8-knockdown MDA-MB-231 cells. (G) MTT was performed in FUT8-knockdown MDA-MB-231 cells. ***P<0.001 vs. NC. FUT8, fucosyltranferase 8; p-AKT, phosphorylated protein kinase B; AKT, protein kinase B; NC, negative control.