Figure 5.

In vivo efficacy of β-elemene-paclitaxel in tumor-bearing mice. (A) β-elemene-paclitaxel treatment significantly inhibits tumor growth compared to either β-elemene or paclitaxel treatment in a 24-day observation. (B) β-elemene-paclitaxel treatment increased numbers of apoptotic body and GPR124 expression in tumor tissue. (C) Combined treatment of β-elemene-paclitaxel decreases MMP-3 and VEGF expression levels in tumor tissue. (D) β-elemene-paclitaxel treatment prolongs survival time of tumor-bearing mice. **P<0.01. GPR124, G-protein coupled receptor 124; MTA, metastasis-associated protein 3; VEGF, vascular endothelial growth factor.