Figure 1.

Study flowchart and protocol. (A) Thirty rats were used in the study, with six rats in each group. In group A, physiological saline was administered through intraperitoneal injection and 10 ml of vehicle was administered orally. Rats in group B were orally administered 10 ml of UDCA vehicle. 5-FU was administered on experimental day 2 to rats in groups B-E. In combination with 5-FU administration, rats in groups C-E were administered UDCA on experimental days 1–6 via oral gavage at the indicated doses. (B) UDCA suspension was administered daily by gavage. UDCA, ursodeoxycholic acid; 5-FU, 5-fluorouracil.