Table I.
Association between treatment groups and other clinical parameters.
| Treatment | ||||
|---|---|---|---|---|
| Variable | Parameter | Radiation | Chemoradiation | P-value |
| Sex | 0.2160 | |||
| Female | 34 (24.8) | 26 (18.1) | ||
| Male | 103 (75.2) | 118 (81.9) | ||
| Age | 0.0004 | |||
| <60 years | 54 (39.4) | 88 (61.1) | ||
| ≥60 years | 83 (60.6) | 56 (38.9) | ||
| Smoking index | 0.8450 | |||
| <40 pys | 34 (24.8) | 39 (27.1) | ||
| ≥40 | 43 (31.4) | 55 (38.2) | ||
| N/A | 60 (43.8) | 50 (34.7) | ||
| Anatomic site | 9.65×10−5a | |||
| Oral cavity | 93 (67.9) | 78 (54.2) | ||
| Oropharynx | 2 (1.5) | 4 (2.8) | ||
| Hypopharynx | 36 (26.3) | 31 (21.5) | ||
| Larynx | 6 (4.4) | 31 (21.5) | ||
| Nodal positive | 5.82×10−7 | |||
| <2 | 81 (59.1) | 38 (26.4) | ||
| ≥2 | 35 (25.5) | 69 (47.9) | ||
| N/A | 21 (15.3) | 37 (25.7) | ||
| Nodal extracapsular | 0.0003 | |||
| NO | 74 (54) | 43 (29.9) | ||
| YES | 27 (19.7) | 49 (34) | ||
| N/A | 36 (26.3) | 52 (36.1) | ||
| Margin status | 0.0340 | |||
| Negative | 117 (85.4) | 90 (62.5) | ||
| Positive | 12 (8.8) | 2 (15.3) | ||
| N/A | 8 (5.8) | 32 (22.2) | ||
| Clinical high risk | 4.51×10−9 | |||
| No | 59 (43.1) | 15 (10.4) | ||
| Yes | 49 (35.8) | 86 (59.7) | ||
| N/A | 29 (21.2) | 43 (29.9) | ||
| Tumor grade | 0.0080a | |||
| G1 | 23 (16.8) | 8 (5.6) | ||
| G2 | 74 (54) | 89 (61.8) | ||
| G3 | 39 (28.5) | 33 (22.9) | ||
| G4 | 0 (0) | 2 (1.4) | ||
| N/A | 1 (0.7) | 12 (8.3) | ||
| TNM stage | 0.0010a | |||
| I | 8 (5.8) | 1 (0.7) | ||
| II | 12 (8.8) | 4 (2.8) | ||
| III | 26 (19) | 11 (7.6) | ||
| IV | 79 (57.7) | 93 (64.6) | ||
| N/A | 12 (8.8) | 35 (24.3) | ||
| pT stage | 0.2180 | |||
| T1-2 | 45 (32.8) | 31 (21.5) | ||
| T3-4 | 80 (58.4) | 81 (56.2) | ||
| N/A | 12 (8.8) | 32 (22.2) | ||
| pN stage | 3.47×10−8 | |||
| N0-1 | 80 (58.4) | 33 (22.9) | ||
| N2-3 | 38 (27.7) | 76 (52.8) | ||
| N/A | 19 (13.9) | 35 (24.3) | ||
a
Fisher's exact test. pys, package years; N/A, not available.