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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Neuroimage. 2018 May 4;176:431–445. doi: 10.1016/j.neuroimage.2018.04.073

Table 2.

Medians (top), and means with standard deviations (bottom) for validation measures for all the methods and all the datasets. We highlight the best results in green based on the median values. Among all datasets, our PCA model has the best median on Dice overlap scores and generally on surface distances. Exception is BEaST which achieves a lower maximum surface distances on the LPBA40 and the TBI datasets. In addition, our model also has the best mean and variance for the Dice overlap scores and the surface distances on most of these datasets.

Dataset: IBSR
PCA ROBEX BEaST* MASS BET BSE CNN
Dice(%) 97.07
96.99±0.53		 95.09
94.98±1.17		 96.94
95.07±7.50		 92.23
86.76±11.06		 95.66
95.16±0.96		 95.68
89.54±21.76		 84.50
81.10±12.07
Avg Dist(mm) 0.71
0.79±0.27		 1.52
1.51±0.56		 0.74
1.48±2.76		 2.50
4.84±4.54		 1.31
1.49±0.47		 1.18
4.16±10.53		 4.62
5.59±3.10
95% Dist(mm) 2.83
2.84±0.43		 4.18
4.50±1.58		 3.00
5.19±9.79		 8.73
13.66±11.81		 3.61
4.22±1.39		 5.00
12.27±20.83		 20.05
22.25±9.41
Max Dist(mm) 9.30
11.97±8.14		 15.55
17.30±8.40		 11.74
15.60±13.41		 24.20
25.76±12.94		 15.68
17.91±7.85		 16.57
24.93±23.32		 39.10
41.10±8.14
Sensitivity(%) 99.06
98.99±0.46		 99.47
99.33±0.54		 98.98
96.70±10.12		 98.77
98.52±0.77		 99.57
99.09±0.93		 97.08
88.68±22.86		 74.87
70.96±15.89
Specificity(%) 99.48
99.44±0.21		 98.89
98.90±0.51		 99.48
99.32±0.37		 97.88
96.11±3.81		 99.12
98.98±0.46		 99.58
99.15±1.67		 99.85
99.80±0.19
Dataset: LPBA40
PCA ROBEX BEaST MASS BET BSE CNN
Dice(%) 97.41
97.32±0.42		 96.74
96.74±0.24		 96.80
94.25±15.29		 97.08
97.03±0.57		 96.92
96.70±0.78		 96.77
96.29±2.26		 95.80
95.70±0.74
Avg Dist(mm) 0.76
0.79±0.12		 0.97
0.97±0.07		 0.97
3.36±14.83		 0.85
0.88±0.21		 0.97
1.06±0.27		 0.92
1.11±0.81		 1.34
1.39±0.37
95% Dist(mm) 2.28
2.27±0.32		 2.98
2.97±0.26		 2.86
6.45±23.19		 2.36
2.50±0.97		 3.46
3.92±1.24		 2.62
3.46±3.38		 3.11
3.56±1.56
Max Dist(mm) 9.73
10.83±3.76		 12.89
13.81±3.47		 8.80
12.89±24.44		 10.71
11.53±4.04		 14.44
15.14±3.75		 13.61
15.54±7.74		 16.91
19.55±8.17
Sensitivity(%) 97.10
96.81±1.23		 96.15
96.33±0.85		 94.76
92.70±15.12		 95.05
95.15±1.08		 98.70
98.66±0.54		 94.85
94.02±4.10		 92.79
92.62±1.46
Specificity(%) 99.62
99.61±0.16		 99.54
99.49±0.16		 99.80
99.70±0.21		 99.86
99.83±0.12		 99.09
99.04±0.34		 99.81
99.79±0.09		 99.85
99.83±0.07
Dataset: BRATS
PCA ROBEX BEaST* MASS BET BSE CNN
Dice(%) 96.34
96.16±0.92		 95.15
94.83±1.49		 94.99
93.29±7.00		 96.20
95.71±1.39		 94.40
90.95±13.41		 84.21
84.91±8.89		 1.75
21.89±29.54
Avg Dist(mm) 0.97
1.00±0.31		 1.31
1.54±0.70		 1.38
2.28±3.34		 1.03
1.17±0.56		 1.68
7.58±25.30		 4.65
4.37±3.61		 55.88
44.87±29.05
95% Dist(mm) 4.15
4.35±1.27		 5.23
6.03±2.50		 5.01
7.71±9.29		 4.62
4.87±2.04		 5.87
6.18±3.53		 13.52
13.92±13.00		 78.45
73.85±38.77
Max Dist(mm) 12.03
15.26±9.32		 12.83
16.42±8.80		 15.03
20.32±14.57		 13.29
16.43±8.97		 17.49
22.78±22.61		 33.95
32.02±22.38		 87.73
86.60±36.92
Sensitivity(%) 96.16
96.17±1.84		 95.82
94.95±2.88		 97.45
97.06±2.66		 94.46
93.62±2.87		 94.92
94.77±3.82		 74.28
77.80±13.43		 0.89
16.17±24.73
Specificity(%) 99.33
99.29±0.25		 99.16
98.98±0.65		 98.68
97.28±5.46		 99.73
99.62±0.28		 98.90
93.69±22.08		 99.82
99.29±2.38		 100.00
99.97±0.05
Dataset: TBI
PCA ROBEX BEaST MASS BET BSE CNN
Dice(%) 96.40
96.28±0.85		 93.71
93.60±1.00		 95.04
95.06±0.96		 95.11
95.42±0.96		 95.40
95.14±1.12		 92.64
91.00±4.31		 91.51
90.40±5.07
Avg Dist(mm) 1.20
1.22±0.30		 2.12
2.20±0.40		 1.60
1.62±0.33		 1.61
1.53±0.33		 1.50
1.57±0.40		 2.23
3.15±1.66		 3.20
3.46±1.75
95% Dist(mm) 3.37
3.41±0.85		 6.20
5.99±0.97		 6.24
5.86±1.44		 4.90
4.59±0.77		 5.06
5.57±1.91		 9.46
13.07±7.11		 14.97
16.04±8.72
Max Dist(mm) 16.13
15.54±5.03		 18.25
18.89±5.12		 15.09
17.27±4.60		 15.65
16.08±4.16		 17.46
18.53±4.59		 27.16
31.96±12.71		 41.49
37.06±10.09
Sensitivity(%) 97.82
97.76±0.92		 98.91
98.64±0.93		 92.12
92.89±2.44		 98.74
98.68±0.66		 93.98
93.65±1.87		 87.51
85.65±8.17		 85.69
83.77±8.58
Specificity(%) 99.03
99.07±0.26		 98.09
97.75±0.93		 99.63
99.57±0.22		 98.64
98.59±0.47		 99.41
99.44± 0.11		 99.82
99.54±0.86		 99.80
99.81±0.07