Table 3.
Significant Odds Ratios (95% CI) for Variables in Model
| Comparison | Worse Outcome | IKDC | KOOS | Marx | |||||
|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Pain | ADL | Sports/Rec | QOL | |||||
|
| |||||||||
| Baseline Outcome Score | lower baseline score | 1.03 (1.03, 1.04) p<0.0001 |
1.02 (1.02, 1.03) p<0.0001 |
1.03 (1.02, 1.03) p<0.0001 |
1.03 (1.02, 1.04) p<0.0001 |
1.01 (1.01, 1.02) p<0.0001 |
1.02 (1.01, 1.03) p<0.0001 |
1.08 (1.06, 1.11) p<0.0001 |
|
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| |||||||||
| Patient Demographics | |||||||||
|
| |||||||||
| Age | older age | 1.02 (1.01, 1.04) p=0.0007 |
1.02 (1.01, 1.04) p=0.0003 |
1.02 (1.01, 1.03) p=0.003 |
1.02 (1.01, 1.04) p=0.0007 |
0.97 (0.96, 0.98) p<0.0001 |
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|
| |||||||||
| Gender | male vs. female | females | 1.30 (1.04, 1.62) p=0.021 |
1.37 (1.09, 1.71) p=0.006 |
1.70 (1.38, 2.10) p<0.0001 |
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|
| |||||||||
| BMI | higher BMI | 0.96 (0.93, 0.98) p=0.0005 |
0.94 (0.92, 0.96) p<0.0001 |
0.96 (0.93, 0.98) p=0.0006 |
0.97 (0.94, 0.99) p=0.016 |
0.96 (0.94, 0.99) p=0.002 |
0.97 (0.95, 1.00) p=0.025 |
0.96 (0.94, 0.98) p=0.001 |
|
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| |||||||||
| Smoking status | never vs. quit | quit smoking | 0.59 (0.42, 0.83) p=0.002 |
0.64 (0.46, 0.89) p=0.008 |
0.68 (0.49, 0.95) p=0.025 |
0.68 (0.48, 0.97) p=0.031 |
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|
| |||||||||
| never vs. current | current smoker | 0.62 (0.43, 0.90) p=0.011 |
0.66 (0.45, 0.95) p=0.026 |
0.60 (0.41, 0.88) p=0.009 |
0.62 (0.42, 0.90) p=0.013 |
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|
| |||||||||
| Education level | lower education | 1.06 (1.03, 1.10) p=0.0006 |
1.06 (1.02, 1.10) p=0.006 |
1.07 (1.02, 1.12) p=0.004 |
1.10 (1.06, 1.15) p<0.0001 |
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|
| |||||||||
| Baseline Marx Activity level | lower activity level | 1.03 (1.01, 1.06) p=0.013 |
1.03 (1.00, 1.06) p=0.031 |
1.03 (1.00, 1.05) p=0.024 |
1.08 (1.06, 1.11) p<0.0001 |
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|
| |||||||||
| Main sport | none vs. football | football | 0.47 (0.23, 0.96) p=0.038 |
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|
| |||||||||
| none vs. other | none | 1.64 (1.06, 2.53) p=0.027 |
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|
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| Competition level | None vs. high school | none | 1.75 (1.01, 3.03) p=0.048 |
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|
| |||||||||
| None vs. recreational | none | 1.70 (1.05, 2.76) p=0.03 |
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|
| |||||||||
| “High-grade” laxity | no vs. yes | yes | 1.08 (1.06, 1.11) p<0.0001 |
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|
| |||||||||
| Surgical Factors | |||||||||
|
| |||||||||
| Reconstruction type | primary vs. revision | revision | 0.37 (0.26, 0.54) p<0.0001 |
0.51 (0.35, 0.75) p=0.0006 |
0.57 (0.39, 0.82) p=0.003 |
0.46 (0.32, 0.66) p<0.0001 |
0.44 (0.30, 0.65) p<0.0001 |
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|
| |||||||||
| Medial meniscus procedure prior to index ACL reconstruction | no vs. yes | yes | 0.52 (0.36, 0.76) p=0.0006 |
0.64 (0.44, 0.93) p=0.019 |
0.60 (0.42, 0.88) p=0.008 |
0.43 (0.31, 0.62) p<0.0001 |
0.53 (0.36, 0.78) p=0.001 |
0.49 (0.33, 0.71) p=0.0002 |
0.48 (0.33, 0.69) p<0.0001 |
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| Lateral meniscus procedure prior to index ACL reconstruction | no vs. yes | yes | 0.54 (0.32, 0.90) p=0.019 |
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| Lateral meniscus pathology | no tear vs. excision | excision | 0.80 (0.64, 1.00) p=0.05 |
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| |||||||||
| AC Medial pathology | normal vs. Grades 3–4 | Grades 3–4 | 0.70 (0.49, 0.99) p=0.047 |
0.65 (0.45, 0.94) p=0.022 |
0.68 (0.48, 0.98) p=0.036 |
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|
| |||||||||
| AC Lateral pathology | normal vs. Grades 3–4 | Grades 3–4 | 0.58 (0.39, 0.86) p=0.008 |
0.57 (0.38, 0.86) p=0.006 |
0.66 (0.44, 0.99) p=0.043 |
0.60 (0.40, 0.90) p=0.013 |
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|
| |||||||||
| AC Lateral pathology | normal vs. fracture lines | linear crack/fracture lines | 0.61 (0.43, 0.86) p=0.005 |
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|
| |||||||||
| AC Patellofemoral pathology | normal vs. Grades 3–4 | Grades 3–4 | 0.58 (0.41, 0.83) p=0.003 |
0.46 (0.32, 0.66) p<0.0001 |
0.53 (0.37, 0.77) p=0.0009 |
0.58 (0.39, 0.84) p=0.005 |
0.51 (0.35, 0.74) p=0.0004 |
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|
| |||||||||
| Intermediate Variables | |||||||||
|
| |||||||||
| 2-year Outcome score | lower 2 year score | 1.06 (1.06, 1.07) p<0.0001 |
1.06 (1.06, 1.07) p<0.0001 |
1.03 (1.02, 1.03) p<0.0001 |
1.08 (1.07, 1.10) p<0.0001 |
1.01 (1.01, 1.02) p<0.0001 |
1.05 (1.04, 1.05) p<0.0001 |
1.15 (1.12, 1.18) p<0.0001 |
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|
| |||||||||
| 2-year Marx activity level | lower activity level | 1.03 (1.01, 1.05) p=0.015 |
1.03 (1.01, 1.06) p=0.011 |
1.03 (1.01, 1.05) p=0.015 |
1.15 (1.12, 1.18) p<0.0001 |
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|
| |||||||||
| 2-year BMI | higher BMI | 0.97 (0.95, 1.00) p=0.0005 |
0.94 (0.92, 0.96) p<0.0001 |
0.96 (0.94, 0.99) p=0.004 |
0.97 (0.94, 1.00) p=0.037 |
0.97 (0.94, 0.99) p=0.011 |
0.96 (0.93, 0.99) p=0.002 |
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|
| |||||||||
| 2-year Smoking status | never vs. quit | quit smoking | 0.70 (0.52, 0.94) p=0.017 |
0.71 (0.53, 0.94) p=0.019 |
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|
| |||||||||
| never vs. current | current smoker | 0.59 (0.39, 0.89) p=0.011 |
0.62 (0.41, 0.92) p=0.018 |
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|
| |||||||||
| 2-year Subequent Surgery (ipsilateral knee) | none vs. scope | scope | 0.52 (0.38, 0.71) p<0.0001 |
0.50 (0.36, 0.69) p<0.0001 |
0.41 (0.30, 0.55) p<0.0001 |
0.54 (0.40, 0.74) p=0.0001 |
0.42 (0.31, 0.57) p<0.0001 |
2.24 (1.47, 3.41) p=0.0002 |
|
|
| |||||||||
| none vs. revision ACL reconstruction | Revision ACL reconstruction | 0.48 (0.33, 0.71) p=0.0002 |
0.48 (0.32, 0.70) p=0.0002 |
0.39 (0.27, 0.58) p<0.0001 |
0.51 (0.34, 0.77) p=0.0013 |
0.34 (0.23, 0.50) p<0.0001 |
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|
| |||||||||
| 2-year Subequent Surgery (contralateral knee) | none vs. scope | scope | 1.48 (1.04, 2.12) p=0.031 |
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|
| |||||||||
| none vs. ACL reconstruction | ACL reconstruction | ||||||||
|
| |||||||||
| 6-year Outcome score | lower 6 year score | 1.10 (1.09, 1.11) p<0.0001 |
1.10 (1.09, 1.10) p<0.0001 |
1.03 (1.02, 1.03) p<0.0001 |
1.12 (1.11, 1.14) p<0.0001 |
1.01 (1.01, 1.02) p<0.0001 |
1.07 (1.07, 1.08) p<0.0001 |
1.24 (1.21, 1.27) p<0.0001 |
|
|
| |||||||||
| 6-year Marx activity level | lower activity level | 1.04 (1.02, 1.06) p=0.0004 |
1.04 (1.02, 1.07) p=0.002 |
1.24 (1.21, 1.27) p<0.0001 |
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|
| |||||||||
| 6-year BMI | higher BMI | 0.95 (0.93, 0.97) p<0.0001 |
0.96 (0.94, 0.99) p=0.002 |
0.96 (0.94, 0.99) p=0.003 |
0.98 (0.95, 1.00) p=0.036 |
0.95 (0.93, 0.98) p<0.0001 |
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|
| |||||||||
| 6-year Smoking status | never vs. quit | quit smoking | 0.74 (0.57, 0.98) p=0.034 |
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|
| |||||||||
| never vs. current | current smoker | 0.65 (0.45, 0.93) p=0.017 |
0.61 (0.42, 0.87) p=0.006 |
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|
| |||||||||
| 6-year Subsequent Surgery (ipsilateral knee) | none vs. scope | scope | 0.57 (0.42, 0.76) p=0.0001 |
0.55 (0.41, 0.74) p<0.0001 |
0.41 (0.31, 0.55) p<0.0001 |
0.58 (0.42, 0.78) p=0.0004 |
0.42 (0.31, 0.56) p<0.0001 |
1.71 (1.15, 2.55) p=0.008 |
|
|
| |||||||||
| none vs. revision ACL reconstruction | Revision ACL reconstruction | 0.58 (0.40, 0.86) p=0.006 |
0.55 (0.38, 0.81) p=0.002 |
0.38 (0.26, 0.55) p<0.0001 |
0.61 (0.41, 0.92) p=0.018 |
0.32 (0.22, 0.47) p<0.0001 |
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|
| |||||||||
| 6-year Subsequent Surgery (contralateral knee) | none vs. scope | scope | |||||||
|
| |||||||||
| none vs. ACL reconstruction | ACL reconstruction | ||||||||
Key: ADL = activities of daily living; sports/rec = sports and recreation; QOL = quality of life; BMI = body mass index; AC = articular cartilage; ACL = anterior cruciate ligament