TABLE 2.
Multivariate Analysis of Freedom From Biochemical Failure
| Variables | Unadjusted for Propensity Score
|
Adjusted for Propensity Score
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Treatment | < 0.01 | 0.06 | ||||
| SRT | 1.00 | Reference group | 1.00 | Reference group | ||
| ART | 0.38 | 0.21, 0.71 | 0.51 | 0.26, 1.02 | ||
| Time from RP to RT | 1.00 | 0.99, 1.01 | 0.61 | 1.01 | 0.99, 1.02 | 0.46 |
| Seminal vesicle invasion | < 0.01 | < 0.01 | ||||
| No | 1.00 | Reference group | 1.00 | Reference group | ||
| Yes | 2.40 | 1.35, 4.28 | 3.26 | 1.85, 5.73 | ||
| Extracapsular extension | 0.43 | 0.27 | ||||
| No | 1.00 | Reference group | 1.00 | Reference group | ||
| Yes | 1.35 | 0.64, 2.85 | 1.49 | 0.73, 3.02 | ||
| Positive margin | 0.58 | 0.37 | ||||
| No | 1.00 | Reference group | 1.00 | Reference group | ||
| Yes | 1.23 | 0.59, 2.55 | 1.37 | 0.69, 2.70 | ||
| Gleason score | ||||||
| ≤6 | 1.00 | Reference group | 1.00 | Reference group | ||
| 7 | 0.97 | 0.43, 2.18 | 0.94 | 0.85 | 0.39, 1.85 | 0.69 |
| 8–10 | 1.69 | 0.72, 3.95 | 0.23 | 1.28 | 0.56, 2.93 | 0.56 |
| Treatment field | 0.55 | 0.34 | ||||
| Prostatic Fossa | 1.00 | Reference group | 1.00 | Reference group | ||
| Prostatic fossa + pelvis | 0.83 | 0.45, 1.53 | 0.74 | 0.4, 1.36 | ||
| ADT | 0.43 | 0.05 | ||||
| No | 1.00 | Reference group | 1.00 | Reference group | ||
| Yes | 1.31 | 0.67, 2.56 | 1.93 | 1.0, 3.7 | 0.05 | |
| Age | 1.01 | 0.97, 1.04 | 0.66 | 0.97 | 0.92, 1.01 | 0.13 |
ADT indicates androgen deprivation therapy; ART, adjuvant radiation therapy; CI, confidence interval; HR, hazard ratio; RP, radical prostatectomy; RT, radiation therapy; SRT, salvage radiation therapy.