Table 2.
Change in vitamin D metabolites and related markers of mineral metabolism
(Mean values and standard deviations)
| Parameters | 0–12-week change | 0–18-week change | ||||||
|---|---|---|---|---|---|---|---|---|
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| Ergocalciferol | Cholecalciferol | Ergocalciferol | Cholecalciferol | |||||
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| Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Total 25(OH)D (ng/ml)* | 30·7 | 15·3 | 45·0† | 16·5 | 17·6 | 8·9 | 22·4 | 12·7 |
| 25(OH)D2 (ng/ml)* | 39·8 | 16·0 | −1·5‡ | 2·8 | 24·1 | 9·4 | −1·6‡ | 2·9 |
| 25(OH)D3 (ng/ml)* | − 11·9 | 4·8 | 47·1‡ | 15·6 | − 9·5 | 4·9 | 24·4‡ | 12·0 |
| Total 1,25(OH)2D (pg/ml)§ | 4·9 | 12·2 | 4·8 | 14·7 | 4·6 | 14·9 | −0·3 | 14·6 |
| 1,25(OH)2D2 (pg/ml)§ | 20·3 | 12·8 | −2·6‡ | 7·8 | 16·8 | 17·8 | −3·4‡ | 8·6 |
| 1,25(OH)2D3 (pg/ml)§ | − 17·7 | 9·7 | 8·6‡ | 14·2 | − 15·8 | 8·7 | 5·1‡ | 12·2 |
| Ca (mmol/l) | 0·0 | 0·1 | 0·0 | 0·1 | – | – | ||
| P (mmol/l) | 0·0 | 0·2 | 0·0 | 0·2 | – | – | ||
| PTH (pg/ml)|| | 2·3 | 38·3 | −15·3|| | 34·5 | – | – | ||
PTH, parathyroid hormone; 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)2D, 1,25-dihydroxyvitamin D.
For the comparison between baseline and 18 weeks of the noted parameter, sample sizes were sixteen for the cholecalciferol group and twenty for the ergocalciferol group.
P < 0·01 for between-group differences at the noted time interval from the linear mixed model.
P < 0·001 for between- group differences at the noted time interval from the linear mixed model.
For comparison between baseline and 18 weeks of the noted parameter, sample sizes were sixteen for the cholecalciferol group and nineteen for the ergocalciferol group.
Linear mixed model of ranks used for analysis because of violations in normality assumptions for linear mixed model of raw (unranked) measures resulted in P = 0·14; however, using relative change from baseline due to the high difference in baseline PTH between groups, this comparison becomes significant (P = 0·02).