Table 2.
Association between E2F2 genotypes and SCCOP recurrence in patients with SCCOP (N=1,008).
| Genotype | No. of recurrence/no. of patients | 5-year recurrence rate | Log-rank p values | aHR1, 95% CI |
|---|---|---|---|---|
| E2F2-rs6667575 | ||||
| GG(Ref.) | 88/474 | 0.17 | 0.594 | 1.0 |
| GA+AA | 93/534 | 0.18 | 0.9 (0.7-1.2) | |
| E2F2-rs3218121 | ||||
| GG(Ref.) | 152/885 | 0.18 | 0.100 | 1.0 |
| GA+AA | 29/123 | 0.24 | 1.3 (0.8-1.9) | |
| E2F2-rs2742976 | ||||
| GT/TT(Ref.) | 138/603 | 0.24 | <0.001 | 1.0 |
| GG | 43/405 | 0.11 | 0.4 (0.3-0.6) | |
| E2F2-rs3218123 | ||||
| GT/TT(Ref.) | 128/461 | 0.30 | <0.001 | 1.0 |
| GG | 53/547 | 0.09 | 0.3 (0.2-0.5) | |
| E2F2-rs3218148 | ||||
| AA(Ref.) | 63/415 | 0.16 | 0.060 | 1.0 |
| AG+GG | 118/593 | 0.21 | 1.3 (0.9-1.8) | |
aHR: adjusted hazard ratio.
1
Adjusted for age, sex, ethnicity, smoking status, alcohol use status, stage, comorbidity, and treatment.
Ref::Reference group.