Table 3.
Associations between average and standard deviation of immune marker predicting cognitive impairment among HIV+ and HIV− women separately as well as in the overall sample.
| HIV+ | HIV− | Overall | |
|---|---|---|---|
|
|
|||
| Log levels | Impairment (vs. none) OR (95%CI) |
Impairment(vs. none) OR (95%CI) |
Impairment(vs. none) OR (95%CI) |
| Mean | |||
| IL1-β | 0.99 (0.68–1.45) | 1.03 (0.78–1.36) | 1.02 (0.81–1.27) |
| IL-18 | 1.51 (0.60–3.77) | 1.30 (0.52–3.24) | 1.40 (0.73–2.67) |
| sTNFRII | 1.18 (0.24–5.93) | 0.58 (0.09–3.66) | 0.87 (0.26–2.90) |
| sTNFRI | 0.24 (0.04–1.39) | 0.10 (0.01–0.95)* | 0.16 (0.04–0.64)** |
| MCP-1 | 1.55 (0.42–5.64) | 0.92 (0.27–3.16) | 1.18 (0.49–2.87) |
| IP-10 | 1.40 (0.75–2.63) | 1.16 (0.54–2.50) | 1.30 (0.80–2.11) |
| TNF-α | 1.36 (0.50–3.69) | 0.87 (0.32–2.36) | 1.09 (0.54–2.19) |
| TRAIL | 1.62 (0.46–5.69) | 1.69 (0.42–6.84) | 1.65 (0.65–4.20) |
| MIP-1β | 2.78 (0.67–11.24) | 1.46 (0.40–5.38) | 1.99 (0.77–5.19) |
| IL-6 | 1.31 (0.89–1.93) | 1.19 (0.87–1.65) | 1.24 (0.97–1.59)T |
| IL-16 | 0.72 (0.36–1.44) | 0.67 (0.29–1.54) | 0.70 (0.41–1.19) |
| IL-10 | 1.12 (0.76–1.65) | 1.13 (0.80–1.59) | 1.13 (0.87–1.45) |
| MMP-9 | 0.58 (0.20–1.67) | 0.74 (0.27–1.98) | 0.66 (0.32–1.36) |
| CRP | 1.02 (0.71–1.47) | 0.70 (0.43–1.16) | 0.89 (0.67–1.19) |
| Standard deviation | |||
| IL1-β | 1.13 (0.75–1.71) | 1.24 (0.67–2.29) | 1.16 (0.83–1.64) |
| IL-18 | 1.38 (0.15–12.72) | 0.67 (0.02–28.69) | 1.15 (0.17–7.71) |
| sTNFRII | 0.63 (0.01–29.74) | 2.70 (0.01–704) | 1.01 (0.04–23.77) |
| sTNFRI | 42.84 (0.26–999) | 0.26 (0.00–39.96) | 3.53 (0.11–108.14) |
| MCP-1 | 1.43 (0.07–28.73) | 0.92 (0.27–3.16) | 5.91 (0.55–63.33) |
| IP-10 | 0.91 (0.20–4.18) | 2.26 (0.21–24.27) | 1.20 (0.34–4.27) |
| TNF-α | 3.03 (0.39–23.69) | 1.18 (0.12–11.91) | 2.02 (0.44–9.26) |
| TRAIL | 0.41 (0.05–3.16) | 0.58 (0.03–11.44) | 0.45 (0.09–2.45) |
| MIP-1β | 1.32 (0.14–12.67) | 8.60 (0.32–228) | 2.52 (0.40–15.83) |
| IL-6 | 1.09 (0.68–1.73) | 1.03 (0.55–1.92) | 1.07 (0.73–1.55) |
| IL-16 | 1.09 (0.23–5.18) | 7.24 (0.42–124.86) | 1.78 (0.46–6.85) |
| IL-10 | 0.88 (0.50–1.53) | 1.24 (0.62–2.49) | 1.00 (0.65–1.55) |
| MMP-9 | 2.11 (0.28–15.64) | 6.37 (0.71–57.11) | 3.59 (0.83–15.62)⊤ |
| CRP | 3.78 (1.09–13.17)* | 4.21 (1.14–15.49)* | 3.99 (1.62–9.79)** |
Note.
**
p<0.01.
*
p<0.05.
†
p=0.06.
⊤
p=0.08. bold is significant at p<0.05; bold and italic is a trend at p<0.09.