Table 4.
Results of Logistic Regression Models of the Transition in Cognitive Diagnosis Compared With Stable Diagnosis
| Outcomes | Unadjusted OR | Adjusted OR | Adjusted p valuea |
|---|---|---|---|
| Normal to MCI vs normal to normal | |||
| TSDD: All ACB | 1.18 (0.99–1.42) | 1.12 (0.93–1.36) | 0.2290 |
| TSDD: Strong ACB | 1.16 (1.04–1.29) | 1.15 (1.01–1.31) | 0.0342 |
| MCI to Normal vs MCI to MCI | |||
| TSDD: All ACB | 0.93 (0.82–1.05) | 0.92 (0.81–1.05) | 0.2121 |
| TSDD: Strong ACB | 0.96 (0.87–1.06) | 0.95 (0.86–1.05) | 0.3266 |
ACB = anticholinergic cognitive burden; MCI = mild cognitive impairment; OR = odds ratio; TSDD = total standard daily dose.
a
Adjusted p value includes age, sex, race, education, history of stroke, history of congestive heart failure, and highest tertile of 10-year TSDD for strong anticholinergics.