Table 2.
Spatial and temporal variability of proliferation and cell cycle markers
| Ki67 | MCM2 | Cyclin D1 | Cyclin A | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Level | Visit 1 | Visit 2 | CV Visit 1 | Visit 1 | Visit 2 | CV Visit 1 | Visit 1 | Visit 2 | CV Visit 1 | Visit 1 | Visit 2 | CV Visit 1 |
| vs. Visit 2 | vs. visit 2 | vs. visit 2 | vs. visit 2 | |||||||||
| Distal | 6.8% | 2.3% | 77.7% | 2.0% | 5.2% | 71.7% | 1.2% | 3.0% | 69.7% | 1.1% | 1.1% | 0% |
| Mid | 4.0% | 3.8% | 5.3% | 2.1% | 4.5% | 61.3% | 0.8% | 0.9% | 11.9% | 1.2% | 1.7% | 32.6% |
| Proximal | 4.4% | 3.5% | 22.3% | 2.2% | 4.2% | 54.3% | 1.0% | 0.5% | 57.2% | 1.3% | 1.6% | 20.5% |
| P value | NS | 0.01 | – | NS | NS | – | NS | 0.03 | – | NS | NS | – |
| CV* | 29.9% | 25% | 4.7% | 11% | 20% | 91.5% | 8.3% | 21.9% | ||||
*
CV, coefficient of variation calculated between levels for each visit