Table 3.

Hazard ratios with 95% confidence intervals for the associations between prediagnosis weight loss and risk of all-cause mortality in a prospective cohort of esophageal cancer patients, 2009–2015

	First tertile	Second tertile	Third tertile	p trend
All patients
Model 1	1 (referent)	2.34 (1.20–4.71)	2.92 (1.47–5.78)	0.002
Model 2	1 (referent)	2.44 (1.23–4.84)	3.09 (1.55–6.16)	0.001
Model 3	1 (referent)	2.09 (1.00–4.37)	2.02 (0.94–4.33)	0.09
Model 4	1 (referent)	1.94 (0.93–4.07)	1.53 (0.68–3.44)	0.36
T Stages 1 & 2
Model 1	1 (referent)	4.68 (1.17–18.8)	5.75 (1.15–28.6)	0.01
Model 2	1 (referent)	4.70 (1.17–18.9)	6.97 (1.39–34.8)	0.008
Model 3	1 (referent)	5.69 (1.06–30.5)	8.26 (1.11–61.5)	0.03
Model 4†	n/a	n/a	n/a	n/a
T Stages 3 & 4
Model 1	1 (referent)	1.65 (0.68–3.96)	1.45 (0.59–3.58)	0.45
Model 2	1 (referent)	1.69 (0.70–4.12)	1.48 (0.60–3.66)	0.43
Model 3	1 (referent)	1.52 (0.61–3.78)	0.82 (0.30–2.21)	0.64
Model 4	1 (referent)	1.19 (0.47–3.00)	0.64 (0.23–1.75)	0.32

Model 1: unadjusted.

Model 2: adjusted for BMI one year prior to diagnosis.

Model 3: adjusted for BMI one year prior to diagnosis and treatment received.

Model 4 (full model): adjusted for BMI one year prior to diagnosis, treatment received, and histology.

^†Model 3 represents the full model for the stratum of T stages 1 & 2.