Table 3.
Antibacterial activities (MICs, μg/mL) and cytotoxic activities (IC50, μM) of huanglongmycin A–C (7–9). S. aureus 29213, Staphylococcus aureus ATCC 29213; MSSA, Methicillin-sensitive Staphylo-coccus aureus; MRSA, Methicillin-resistant Staphylococcus aureus; –, not tested.
| Bioactivity | Bacteria/cancer cells | Compounds | |||||
|---|---|---|---|---|---|---|---|
| Linezolid | Chloramphenicol | Mitomycin | HLM A (7) | HLM B (8) | HLM C (9) | ||
| Antibacterial activities | S. aureus ATCC 29213 | 1 | 2 | – | >64 | 64 | >64 |
| MSSA | 1 | 2 | – | >64 | 64 | >64 | |
| MRSA | 1 | 2 | – | >64 | 64 | >64 | |
| E. coli | >64 | 8 | – | 64 | >64 | >64 | |
| K. pneumoniae | >64 | 8 | – | >64 | >64 | >64 | |
| P. aeruginosa | >64 | >64 | – | 64 | >64 | >64 | |
| Cytotoxicity | A549 | – | – | 0.9 ± 0.1 | 13.8 ± 1.5 | >60 | >60 |
| SKOV3 | – | – | – | 41.3 ± 7.0 | >60 | >60 | |
| Hela | – | – | – | 43.7 ± 2.3 | >60 | >60 | |
| Caco-2 | – | – | – | 43.2 ± 2.1 | >60 | >60 | |