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. 2018 Jun 14;9(13):2389–2396. doi: 10.7150/jca.24079

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Fig 1 — The PDE4a was up-regulated in HCC tissues and HCC cell lines. A. The representative picture of PDE4a IHC staining in adjacent liver tissues (a) and HCC tissues (b). There was significantly more PDE4a expression in HCC tissues in contrast to adjacent liver tissues; B. Mann-Whitney U test demonstrated that PDE4a expression in HCC tissues was apparently higher than one in adjacent liver tissues; C. Both qRT-PCR and Western immunoblotting showed that there was the higher level of PDE4a expression in 5 kinds of HCC cell line (Huh7, Hep3B, MHCC97h, SK-Hep1 and PLC/PRF/5) than human liver cell line LO2. Among 5 kinds of HCC cell lines, MHCC97h cells had the highest level of PDE4a expression, while there was the least PDE4a expression in Huh7 cells.