Table 1.

Demographic information and clinical feature of 210 HCC patients

Clinicopathological features		No. of Patients		X2	P
		Low PDE4a	High PDE4a
Age (years)	< 50	15	77	0.015	0.901
	≥ 50	20	98
Gender	Male	21	108	0.036	0.849
	Female	14	67
HBV infection	Present	27	160	6.103	0.014*
	Absent	8	15
Serum AFP level (ng/mL)	< 400	3	34	0.256	0.613
	≥ 400	22	151
Tumor diameter (cm)	< 5	21	69	5.040	0.025*
	≥ 5	14	106
Liver cirrhosis	Present	19	129	5.291	0.021*
	Absent	16	46
Edmondson-Steiner Classification	I + II	17	76	0.313	0.576
	III + IV	18	99
TNM stage	I + II	21	62	7.367	0.007*
	III + IV	14	113
PVTT	Present	2	39	5.098	0.024*
	Absent	33	136
Intra-hepatic metastases	Present	2	39	54.84	<0.001
	Absent	33	136
MVI	Present	8	87	8.492	0.004*
	Absent	27	88