Table 2.
Univariate and multivariate analyses of overall survival for the 2,318 patients with nasopharyngeal carcinoma
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age at diagnosis (years) | ||||
| ≥ 45 vs. < 45 | 1.265 (1.038-1.541) | 0.020 | 1.327 (1.087-1.620) | 0.005 |
| Smoking status | ||||
| Yes vs. no | 1.100 (0.893-1.354) | 0.369 | ||
| Overall stage (7th) | ||||
| III - IV vs. I - II | 2.758 (1.794-4.241) | < 0.001 | 1.778 (1.052-3.007) | 0.032 |
| T category | ||||
| T1 | 1 (reference) | < 0.001 | 1 (reference) | < 0.001 |
| T2 | 2.088 (1.134-3.846) | 1.784 (0.965-3.300) | ||
| T3 | 1.910 (1.064-3.428) | 1.393 (0.754-2.574) | ||
| T4 | 3.456 (1.913-6.243) | 2.493 (1.339-4.643) | ||
| N category | ||||
| N0 | 1(reference) | < 0.001 | 1 (reference) | < 0.001 |
| N1 | 1.913 (1.572-2.326) | 1.316 (1.078-1.606) | ||
| N2 | 1.927 (1.514-2.452) | 1.613 (1.244-2.092) | ||
| N3 | 2.209 (1.727-2.827) | 1.866 (1.430-2.436) | ||
| Treatment | ||||
| RT vs. CT + RT | 1.310 (1.053-1.628) | 0.015 | 1.773 (1.429-2.201) | < 0.001 |
| EBV DNA (copies mL-1) | ||||
| ≥ 2,560 vs. < 2,560 | 1.850 (1.508-2.268) | < 0.001 | 1.434 (1.174-1.753) | < 0.001 |
| Hemoglobin (g/L) | ||||
| < 120 vs. ≥ 120 | 1.123 (0.838-1.504) | 0.437 | ||
| Albumin (g/L) | ||||
| < 45 vs. ≥ 45 | 1.187 (0.973-1.448) | 0.090 | ||
| BMI (Kg/m2) | ||||
| < 18.5 | 1 (reference) | 0.031 | 1 (reference) | 0.470 |
| 18.5-25 | 1.570 (1.029-2.397) | 1.051 (0.621-1.779) | ||
| ≥ 25 | 1.323 (1.046-1.674) | 0.743 (0.344-1.603) | ||
| RDW | ||||
| > 13.55 vs. ≤ 13.55 | 1.288 (1.022-1.623) | 0.032 | 1.121 (0.850-1.478) | 0.418 |
| COR-BMI | ||||
| 0 | 1 (reference) | 0.007 | 1 (reference) | 0.013 |
| 1 | 1.311 (1.022-1.682) | 1.239 (1.012-1.590) | ||
| 2 | 2.403 (1.335-4.323) | 2.367 (1.311-4.274) | ||
Abbreviations: COR-BMI = Combination of red blood cell distribution width and body mass index; CI = confidence interval; HR = hazard ratio; N = node; T = tumor; multivariate analyses adjusted for age, overall stage, T category, N category, treatment, EBV DNA copy number, hemoglobin, albumin, NLR and COR-BMI.