Table 2.
Association between methylation status of FAT4, SOX11 and GC risk.
| Methylation status | Control (%) | Case (%) | OR (95% CI) | P | ORa (95% CI) | P a | ORb (95% CI) | P b | |
|---|---|---|---|---|---|---|---|---|---|
| FAT4 | Nm | 167 (43.5) | 114 (30.8) | 1.000 | 1.000 | 1.000 | |||
| Pm | 45 (11.7) | 57 (15.4) | 1.856 (1.174-2.932) | 0.008* | 1.751 (1.038-2.952) | 0.036* | 2.204 (1.168-4.159) | 0.015* | |
| Hm | 172 (44.8) | 199 (53.8) | 1.695 (1.239-2.319) | 0.001* | 1.418 (0.986-2.038) | 0.060 | 1.434 (0.913-2.251) | 0.117 | |
| Tpm | 217 (56.5) | 256 (69.2) | 1.728 (1.282-2.331) | <0.001* | 1.486 (1.052-2.099) | 0.024* | 1.583 (1.031-2.430) | 0.036* | |
| SOX11 | Nm | 162 (42.1) | 131 (36.4) | 1.000 | 1.000 | 1.000 | |||
| Pm | 32 (8.3) | 62 (17.2) | 2.396 (1.475-3.891) | <0.001* | 2.583 (1.467-4.546) | 0.001* | 2.530 (1.289-4.969) | 0.007* | |
| Hm | 191 (49.6) | 167 (46.4) | 1.081 (0.793-1.474) | 0.621 | 0.947 (0.659-1.362) | 0.770 | 0.945 (0.608-1.468) | 0.800 | |
| Tpm | 223 (57.9) | 229 (63.6) | 1.270 (0.945-1.706) | 0.112 | 1.159 (0.822-1.636) | 0.400 | 1.155 (0.760-1.756) | 0.499 | |
Nm, negative methylation; Pm, positive methylation; Hm, heterogeneous methylation; Tpm, total positive methylation
CI, confidence interval; OR, odds ratio. *Statistically significant.
a Adjusted for BMI, occupation, family history of GC, age, gender.
b Adjusted for BMI, occupation, family history of GC, age, gender, regular diet, salt, green vegetables, freshwater fish, garlic, H.pylori, drinking, overnight food, fried food.