Table 3.
Association between methylation status of genes and risk of GC by age.
| Methylation status | < 60 years | ≥ 60 years | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | ORa(95% CI) | P a | OR (95% CI) | P | ORa (95% CI) | P a | |||
| FAT4 | Nm | 1.000 | 1.000 | 1.000 | 1.000 | |||||
| Pm | 1.849 (0.973-3.517) | 0.061 | 1.548 (0.759-3.160) | 0.230 | 1.866 (0.970-3.590) | 0.062 | 1.950 (0.893-4.260) | 0.094 | ||
| Hm | 1.878 (1.223-2.886) | 0.004* | 1.280 (0.788-2.078) | 0.318 | 1.513 (0.953-2.401) | 0.079 | 1.586 (0.905-2.778) | 0.107 | ||
| Tpm | 1.872 (1.244-2.817) | 0.003* | 1.336 (0.845-2.112) | 0.215 | 1.585 (1.020-2.463) | 0.041* | 1.661 (0.971-2.841) | 0.064 | ||
| SOX11 | Nm | 1.000 | 1.000 | 1.000 | 1.000 | |||||
| Pm | 1.986 (0.987-3.997) | 0.054 | 2.105 (0.946-4.683) | 0.068 | 3.038 (1.540-5.993) | 0.001* | 3.342 (1.480-7.545) | 0.004* | ||
| Hm | 0.956 (0.626-1.458) | 0.833 | 0.725 (0.446-1.180) | 0.196 | 1.291 (0.814-2.046) | 0.278 | 1.405 (0.799-2.468) | 0.237 | ||
| Tpm | 1.092 (0.730-1.635) | 0.668 | 0.881 (0.555-1.398) | 0.591 | 1.561 (1.008-2.417) | 0.046* | 1.721 (1.008-2.936) | 0.047* | ||
Nm, negative methylation; Pm, positive methylation; Hm, heterogeneous methylation; Tpm, total positive methylation
CI, confidence interval; OR, odds ratio. *Statistically significant.
aAdjusted for BMI, occupation, family history of GC, gender.