Table 4.
Association between methylation status of genes and risk of GC by H.pylori infection.
| Methylation status | Negative H. pylori infection | Positive H. pylori infection | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | ORa(95% CI) | P a | OR (95% CI) | P | ORa (95% CI) | P a | |||
| FAT4 | Nm | 1.000 | 1.000 | 1.000 | 1.000 | |||||
| Pm | 1.824 (0.951-3.497) | 0.071 | 1.781 (0.821-3.861) | 0.144 | 1.879 (0.979-3.607) | 0.058 | 1.714 (0.819-3.584) | 0.152 | ||
| Hm | 1.540 (0.974-2.435) | 0.065 | 1.168 (0.674-2.026) | 0.580 | 1.762 (1.138-2.728) | 0.011* | 1.522 (0.922-2.513) | 0.101 | ||
| Tpm | 1.602 (1.038-2.471) | 0.033* | 1.295 (0.773-2.169) | 0.326 | 1.785 (1.174-2.713) | 0.007* | 1.560 (0.966-2.521) | 0.069 | ||
| SOX11 | Nm | 1.000 | 1.000 | 1.000 | 1.000 | |||||
| Pm | 2.537 (1.237-5.202) | 0.011* | 3.323 (1.385-7.973) | 0.007* | 2.255 (1.150-4.425) | 0.018* | 2.284 (1.053-4.952) | 0.036* | ||
| Hm | 1.342 (0.846-2.129) | 0.212 | 1.142 (0.648-2.011) | 0.647 | 0.916 (0.597-1.406) | 0.689 | 0.834 (0.510-1.365) | 0.470 | ||
| Tpm | 1.513 (0.973-2.352) | 0.066 | 1.409 (0.823-2.411) | 0.211 | 1.109 (0.739-1.666) | 0.617 | 1.023 (0.641-1.634) | 0.924 | ||
Nm, negative methylation; Pm, positive methylation; Hm, heterogeneous methylation; Tpm, total positive methylation
CI, confidence interval; OR, odds ratio. *Statistically significant.
a Adjusted for BMI, occupation, family history of GC, age, gender