Table 3.
Association between NOTCH4 expression and clinicpathological factors in the validation cohort.
| Variable | n | NOTCH4 Expression | χ2 Value | P value | |
|---|---|---|---|---|---|
| Low | High | ||||
| Gender | 1.132 | 0.287 | |||
| Male | 149 | 65(56.5) | 84(63.2) | ||
| Female | 99 | 50(43.5) | 49(36.8) | ||
| Age | 1.394 | 0.238 | |||
| ≦60 | 152 | 75(65.2) | 77(57.9) | ||
| >60 | 96 | 40(34.8) | 56(42.1) | ||
| T category | 4.367 | 0.113 | |||
| T1/2 | 36 | 23(20.2) | 14(10.5) | ||
| T3 | 51 | 22(19.1) | 29(21.8) | ||
| T4 | 160 | 70(60.9) | 90(67.7) | ||
| N stage | 12.795 | 0.002 | |||
| N0 | 107 | 61(53.0) | 46(34.6) | ||
| N1 | 81 | 25(21.7) | 56(42.1) | ||
| N2 | 60 | 29(25.2) | 31(23.3) | ||
| M stage | 9.689 | 0.002 | |||
| M0 | 215 | 108(93.9) | 107(80.5) | ||
| M1 | 33 | 7(6.1) | 26(19.5) | ||
| Pathological grading | 2.225 | 0.329 | |||
| High | 69 | 28(24.3) | 41(30.8) | ||
| Moderate | 125 | 66(57.4) | 59(44.4) | ||
| Poor | 54 | 21(18.3) | 33(24.8) | ||
| Lymphovascular invasion | 4.718 | 0.030 | |||
| Negative | 194 | 97(84.3) | 97(72.7) | ||
| Positive | 54 | 18(15.7) | 36(27.1) | ||
| Perineural invasion | 0.007 | 0.933 | |||
| Negative | 213 | 99(86.1) | 114(85.7) | ||
| Positive | 35 | 16(13.9) | 19(14.3) | ||
| CEA status | 7.272 | 0.026a | |||
| Normal | 157 | 83(72.2) | 74(55.6) | ||
| High | 82 | 29(25.2) | 53(39.8) | ||
| Unknown | 9 | 3(2.6) | 6(4.5) | ||
a exact χ2 test