Table 4.

Prognostic values of MCM genes expression in HCC OS of TCGA cohort

Gene expression	Patients(n=370)	NO. of event	MST (days)	Crude HR (95% CI)	Crude P	Adjusted HR (95% CI)	Adjusted P §
MCM2
Low	185	54	2116	1		1
High	185	76	1397	1.782(1.256-2.529)	0.001	1.574(1.073-2.309)	0.02
MCM3
Low	185	60	2116	1		1
High	185	70	1372	1.580(1.114-2.242)	0.010	1.456(0.992-2.136)	0.055
MCM4
Low	185	62	1791	1		1
High	185	68	1397	1.408(0.997-1.990)	0.052	1.302(0.895-1.894)	0.167
MCM5
Low	185	59	1.791	1		1
High	185	71	1622	1.386(0.980-1.960)	0.065	1.299(0.893-1.891)	0.172
MCM6
Low	185	54	2131	1		1
High	185	76	1372	1.842(1.297-2.615)	0.001	1.603(1.094-2.350)	0.015
MCM7
Low	185	53	2131	1		1
High	185	77	1149	1.852(1.304-2.632)	0.001	1.793(1.222-2.630)	0.003

Notes: §Adjusted for tumor stage and radical resection. MCM, minichromosome maintenance; HCC, hepatocellular carcinoma; OS, overall survival; MST, median survival time; HR, hazard ratio; CI, confidence interval; TCGA, The Cancer Genome Atlas.