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. 2018 Jun 8;14(9):1099–1108. doi: 10.7150/ijbs.26400

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© Ivyspring International Publisher

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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ZIKV Env, M-Env and prM-Env induced mitotic catastrophe in lentiviruses-transduced PC12 cells. (A) PC12 cells were transduced with LV-ZIKV-prM-Env, LV-ZIKV-M-Env, LV-ZIKV-Env or LV-eGFP at an MOI of 100, immunostained with an anti-His antibody followed by anti-mouse Alexa Fluor 633-conjugated antibody, and then counterstained with DAPI for nuclear staining (Scale bar= 100 μm). Mitotic catastrophe was characterized by the appearance of aberrant nuclei clusters. The number of aberrant nuclei clusters in each treatment condition was counted from 5 random fields per well by an individual who was blinded to the treatment. (B) Data are presented as a percent of the total number of cells on the dish. **: P<0.01 versus with LV-eGFP.