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. 2018 Jun 3;14(9):1033–1040. doi: 10.7150/ijbs.25589

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Effect of KC-derived MMP9 on transcription of MMPs and TIMPs. Total mRNA was extracted from liver at indicated time points. The levels of (A) MMP9, (B) MMP13, (C) MMP2, (D) MMP14, (E) TIMP1 and (F) TIMP2 were analyzed by qRT-PCR. Data were normalized to GAPDH and expressed as mean ± standard deviation. n=5, *p<0.05 (compared with control); ^p<0.05 (compared with the treatment by KCs from MMP9-/- animals). WT, treatment with KCs from wild type mice; KO, treatment with KCs from matrix metalloproteinase-9 deficiency mice.