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. 2018 Jun 25;2018:4327901. doi: 10.1155/2018/4327901

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Copyright © 2018 Zheng Yang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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nNOS-KO abolished the antiremodeling effects of aucubin in vivo. (a) Kaplan-Meier survival analysis of nNOS-KO mice in vehicle-MI and aucubin-MI group during 2 weeks after MI. (b–d) H&E staining ((b) n = 6) and statistical analysis of the infarction area (c) and cross-sectional area ((d) CSA, n = 100+ cells per experimental group). (e) and (f) PSR staining of the heart in the indicated groups [(e) PSR staining (n = 6) and (f) statistical analysis of the LV collagen volume (%), n = 25+ fields per experimental group]. (g) and (h) TUNEL staining (g) (n = 6) and quantitation (h) in the hearts of vehicle and aucubin-treated nNOS-KO mice at 2 weeks post-MI. ^∗P < 0.05 vs. the Vehicle-sham group.