Table I.

Transcriptional changes observed in bystander cells in the context of the RIBE.

Species	Type of ionizing radiation	mRNAs	Other RNAs	Gene Ontology category
Homo sapiens	α	CDKN1A, TP53, CAT, HMOX1, SOD1, GPX1,PRKCE, GJA1, SERPINB2, MMP1, MMP3, MMP10, IL6, IL8, IL33, GDF15, LIF, MT1B, MT1G, MT1E, MT1L, PTGS2 (upregulated)	miR-21, miR-22, miR-29c (upregulated)	Protein modification, cell motility, cell communication, ligand-mediated signaling, ion transport, defense, immunity (upregulated)
	γ	TP53, BAX, CASP2, CDKN1A, NOS2, AREG, EREG, IL11, FGF7, RGS2, FN1, LGALS3, SERPINB2, GABBR1, GALR3, AMHR2, KIT, STK38, HSPC111, INVS, MT-ATP6, MT-ATP8 (upregulated); BCL2, MT-ND1, MT-ND5, MT-ND6 (downregulated)	miR-17-5p, miR-142-3p, miR-142-5p, miR-19a, miR-143, miR-145, miR-663a, let-7i-5p, miR−24-3p, miR-92a-3p, miR-1246, and miR-2861, miR-21, RMST (up); miR-17-3p, miR-19b, miR-15a, miR-16, miR-155, miR-21, miR-18a, SNHG1, SNHG4, SNHG5, SNHG11, SRA1, MALAT1, MATR3, SOX2OT (downregulated)	Cytokine-cytokine receptor interaction, neuroactive ligand-receptor, JAK-STAT signaling, calcium signaling, cell communication (upregulated); purine metabolism, oxidative phosphorylation, cell cycle (downregulated)
	(12)C	EIF2AK4, RAD23B, ATF4, RBBP4, MYCN, NEUROG1, FN1, ANXA1, PIK3C2A, GNA13, IL1RAP, MED18 (upregulated)	–	–
Mus musculus	γ, X-ray	Fadd, Casp8, Rela, Tnfrsf10b, Cdk5r2, Hspa4, Gpx1, Dnaja1, Lig1, Xrcc1, Msh1, Mlh1, Hus1, Exo1 (upregulated)	miR-152-3p, miR-199a-5p, miR-375-5p (upregulated); miR-33-3p, miR-140-3p, miR-200c-5p, miR-669o-5p, miR-744-3p, miR-24, miR-30e, miR-181a, miR-422b, miR-26b (downregulated)	Protein ubiquitination, NRF2-mediated oxidative stress response, actin cytoskeleton, FAK, MAPK, insulin receptor signaling, DNA damage, DNA repair (differentially regulated)
Rattus norvegicus	γ	Cdh1, Eaat2, Tbx18 (downregulated)	–	–
Arabidopsis thaliana	α (40)Ar(+)	AtRAD51, AtRAD54 (upregulated)	–	–

-, data unavailable; RIBE, radiation-induced bystander effect; miR, microRNA.