Table 4.

Clinicopathologic characteristics of lung adenocarcinoma patients with EGFR L858R mutation, stratified by polymorphic genotypes of eNOS 894 G/T (rs1799983)

Variables	GG (N=66)	GT + TT (N=12)	p-value
Tumor AJCC stages, n (%)
I+II	22 (33.3%)	1 (8.3%)	p=0.081
III+IV	44 (66.7%)	11 (91.7%)
Tumor “T” classification, n (%)
T1+T2	50 (75.8%)	7 (58.3%)	p=0.211
T3+T4	16 (24.2%)	5 (41.7%)
Lymph node status, n (%)
Negative	26 (39.4%)	0 (0%)	p=0.008*
Positive	40 (60.6%)	12 (100%)
Distant Metastasis, n (%)
Negative	37 (56.1%)	6 (50.0%)	p=0.698
Positive	29 (43.9%)	6 (50.0%)
Tumor differentiation, n (%)
Good	9 (13.6%)	2 (16.7%)	p=0.912
Moderate	53 (80.3%)	9 (75.0%)
Poor	4 (6.1%)	1 (8.3%)