. 2018 Jun 23;9(14):2571–2579. doi: 10.7150/jca.24824

Table 2.

Subgroup analysis of pooled HR for Rac1 impact on OS and DFS

	OS					DFS
	Number of study (sample size)	HR (95%CI)	I² (%)	P_H	P_Z	Number of study (sample size)	HR (95%CI)	I²	P_H	P_Z
All studies	12 (1571)	2.02 (1.70-2.31)^a	18.2	0.265	<0.001	6 (815)	2.64 (1.74-4.09)^b	60.4	0.027	<0.001
Age≧60y	6 (821)	1.47 (1.07-2.03)^a	0.0	0.532	0.018	2 (168)	1.73 (0.93-3.23)^a	39.5	0.198	0.084
Age<60y	5 (648)	2.06 (1.44-2.93)^a	35.6	0.212	<0.001	2 (312)	2.95 (1.82-4.82)^a	49.5	0.160	<0.001
Asian group	11 (1495)	2.04 (1.71-2.42)^a	24.0	0.215	<0.001	5 (755)	2.58 (1.58-4.21)^b	67.9	0.027	<0.001
European group	1	1.56 (0.61,4.01)	-	-	-	1 (60)	3.22 (1.04-9.98)	-	-	-
Gastric cancer	4 (386)	1.83 (1.27-2.63)^a	0.0	0.466	0.001	-	-	-	-	-
Non-small lung cancer	2 (264)	2.16 (1.45-3.24)^a	0.0	0.843	<0.001	-	-	-	-	-
Other cancers	6 (921)	2.10 (1.52-2.90)^b	52.1	0.063	<0.001	6 (815)	2.64 (1.71,-4.09)^b	60.4	0.027	<0.001
IHC cut off≧33%	4 (613)	1.73 (1.12-2.65)^b	57.8	0.068	<0.001	-	-	-	-	-
IHC cut off<33%	7 (850)	2.35 (1.87-2.85)^b	0.0	0.873	<0.001	5 (707)	3.00 (1.91-4.71)^b	56.6	0.056	<0.001
Follow up<40 month	6 (756)	2.01 (1.58-2.55)^b	0.0	0.792	<0.001	2 (395)	2.02 (1.43-2.87)^a	0.0	0.661	<0.001
Follow up≧40 month	5(755)	2.02 (1.37-3.00)^b	58.7	0.046	<0.001	4 (420)	3.15 (1.67-5.95)^b	66.0	0.032	<0.001
Sample size≧100	8 (1257)	1.94 (1.61-2.34)^a	35.8	0.143	<0.001	5 (755)	2.58 (1.58-4.21^)b	67.9	0.014	<0.001
Sample size<100	4 (314)	2.40 (1.63-3.53)^a	0.0	0.657	<0.001	1 (60)	3.22 (1.04-9.98)	-	-	-
Multivariate analysis	6 (861)	2.42 (1.89-3.10)^a	0.0	0.871	<0.001	4 (432)	2.58 (1.19-5.56)^b	69.8	0.019	0.005
Univariate analysis	6 (750)	1.72 (1.37-2.17)^a	34.8	0.176	<0.001	2 (383)	2.65 (1.55-4.53)^b	61.1	0.109	<0.001
PT: no	10 (1237)	2.21 (1.84-2.66)^a	0.0	0.743	<0.001	5 (653)	2.83 (1.73-4.61)^b	66.0	0.019	<0.001
PT: NA	2 (334)	1.29 (0.85-1.94)^a	49.6	0.159	0.233	1 (162)	1.67 (0.66-4.22)^b	-	-	-