Table 1.
Clinical characteristics of advanced urothelial carcinoma patients grouped by PNI
| All (n, %) | PNI < 40 (%) | PNI ≥ 40 (%) | P value | |
|---|---|---|---|---|
| Age (year) | 0.81 | |||
| < 65 | 74 (52.5) | 22 (29.7) | 52 (70.3) | |
| ≥ 65 | 67 (47.5) | 18 (27.9) | 49 (73.1) | |
| Gender | 0.34 | |||
| Female | 51 (36.2) | 12 (23.5) | 39 (76.5) | |
| Male | 90 (63.8) | 29 (32.2) | 61 (67.8) | |
| ECOG | 0.40 | |||
| 0-1 | 104 (73.8) | 28 (26.9) | 76 (73.1) | |
| ≥ 2 | 37 (26.2) | 13 (35.1) | 24 (64.9) | |
| Renal function (mL/min) | 0.58 | |||
| CCr ≥ 60 | 62 (44.0) | 20 (32.3) | 42 (67.7) | |
| CCr < 60 | 79 (56.0) | 21 (26.6) | 58 (73.4) | |
| Primary site | 0.85 | |||
| Upper tract | 82 (58.2) | 25 (30.5) | 57 (69.5) | |
| Bladder | 54 (38.3) | 15 (27.8) | 39 (72.2) | |
| Multifocal | 5 (3.5) | 1 (20) | 4 (80) | |
| Histopathologic variant | 0.26 | |||
| No | 89 (63.1) | 29 (32.6) | 60 (67.4) | |
| Yes | 52 (36.9) | 12 (23.1) | 40 (76.9) | |
| Visceral metastasis | 0.009 | |||
| No | 67 (47.5) | 12 (17.9) | 55 (82.1) | |
| Yes | 74 (52.5) | 29 (39.2) | 45 (60.8) | |
| Liver metastasis | 0.054 | |||
| No | 115 (81.6) | 29 (25.2) | 86 (74.8) | |
| Yes | 26 (18.4) | 12 (46.2) | 14 (53.8) | |
| Lung metastasis | 0.16 | |||
| No | 96 (68.1) | 24 (25.0) | 72 (75.0) | |
| Yes | 45 (31.9) | 17 (37.8) | 28 (62.2) | |
| Bone metastasis | 0.09 | |||
| No | 116 (82.3) | 30 (25.9) | 86 (74.1) | |
| Yes | 25 (17.7) | 11 (44.0) | 14 (56.0) | |
| WBC (× 103/μL) | 0.005 | |||
| < 10 | 97 (68.8) | 21 (21.6) | 76 (78.4) | |
| ≥ 10 | 44 (31.2) | 20 (45.5) | 24 (54.5) | |
| NLR | < 0.0001 | |||
| < 3 | 55 (39.0) | 3 (5.5) | 52 (94.5) | |
| ≥ 3 | 86 (61.0) | 38 (44.2) | 48 (55.8) | |
| Hemoglobin (g/dL) | < 0.0001 | |||
| ≥ 10 | 103 (73.0) | 18 (17.5) | 85 (82.5) | |
| < 10 | 38 (27.0) | 23 (60.5) | 15 (39.5) | |
| First-line chemotherapy | 0.35 | |||
| Cisplatin-based | 92 (65.2) | 26 (28.3) | 66 (71.7) | |
| Carboplatin-based | 36 (25.5) | 13 (36.1) | 23 (63.9) | |
| Other | 13 (9.2) | 2 (15.4) | 11 (84.6) |
Abbreviation: CCr, clearance of creatinine; ECOG, Eastern Cooperative Oncology Group; PNI, prognostic nutritional index; NLR, neutrophil to lymphocyte ratio; WBC, white blood cell count